Diuretics

Question 1

Give 2 examples of Thiazide like diuretics

Answer 1

Bendroflumethiazide
Indapamide

Question 2

What Drug class is Indapamide?

Answer 2

Thiazide-like Diuretics

Question 3

What is indapamide used for?

Answer 3

Hypertension

Question 4

What is indapamides mechanism of action?

Answer 4

Inhibits Na/Cl co-transporter in the DCT
On the Apical membrane
H2O follows ions

Question 5

Adverse effects of indapamide

Answer 5

Hyperuricaemia (goat) (uric acid crystals build up in joints, fluids, and tissues within the bones)
Hyperglycaemia (diabetes)
Hypercalcaemia
Hypokalaemia

Question 6

What are the DTD interactions of indapamide?

Answer 6

Alcohol
Amlodopine

Question 7

Give an example of K+ sparring diuretic (aldosterone/mineralcorticoud receptor antagonist)

Answer 7

Spironolactone

Question 8

What is spironolactone used for?

Answer 8

HF

Question 9

How does spironolactone act?

Answer 9

Mineralcorticoid receptor antagonist
Aldosterone receptor antagonist: prevents aldosterone action and reduces ENaC expression
Aldosterone normally increases ENaC and Na/K/ATPase pump on principle cells of CD

Question 10

What are the adverse effects of spironolactone?

Answer 10

Gynaecomastia
Hyperkalaemia
severe cutaneous adverse reaction
hypercalcaemia
impotence

Question 11

DTDI of spironolactone

Answer 11

alcohol
amiloride
ACEi
ARBs