Angiotensin II Receptor Blockers (ARBs)

Question 1

Give 2 examples of ARBs

Answer 1

Losartan
Candesartan

Question 2

What are ARBs used for?

Answer 2

Hypertension
HF
(When there is side effect with ACEi)

Question 3

What are the adverse effects of ARBs?

Answer 3

Postural hypotension (low BP that happens when standing after sitting or lying down)
Hyperkalaemia
Hypotension

Question 4

Are there any warnings/contraindications for ARBs

Answer 4

NO

Question 5

What are DTD interactions with ARBs?

Answer 5

Alcohol
K+ sparing diuretics

Question 6

What drug class is losartan?

Answer 6

ARBs

Question 7

What is Losartan used for?

Answer 7

Heart failure
Hypertension

Question 8

What is Losartans mode of action?

Answer 8

AT1 receptors (more effective at inhibiting Ang-II mediated vasoconstriction)
AT2 receptors
Inhibits action of angiotensin 2

Question 9

What are the adverse effects of losartan?

Answer 9

Same as ACE but no BK build up (no dry cough)
Hyperkalaemia
Postural hypotension
Renal failure

Question 10

DTD interactions of Losartan

Answer 10

NSAIDs- Renal impairment

Question 11

What CYP enzyme breaks down Losartan

Answer 11

CYP2C9