Diuretics

Question 1

what is the main location of water reabsorption in the kidney?

Answer 1

The loop of henle. works via a countercurrent mechanaisim driven by the Extrusion of Na that produces hypertonic conditions in the medulla.

Question 2

what part of the nephron do thiazide diuretics act upon

Answer 2

first half of the distal covuluted tubule.

Question 3

where do carbonic anhydrase inhibhibitors act upon

Answer 3

Proximal convuluted tubule.

Question 4

What is a side effect of Sulphanamides?

Answer 4

they are an antibiotic that has a diuresis side effect.

Question 5

what does the thiazide hydrochloro thiazide do?

Answer 5

blocks the Na Cl symporter.

Question 6

Name an ACE inhibitor and what this means for diuretics?

Answer 6

Captopril. if ACE is blocked then AG1 cannot be converted into ACE2 which means alderstrone cannot be released that leads to decreased ADH/Vasopressin release. Less aquaporins integrated into the collecting duct so less retention of water.

Question 7

name an osmotic diuretic and how it works?

Answer 7

Mannitol. works at proximal tubule, thin desending limb, distal tubule and collecting ducts.

impedes water reabsorption and indirectly impedes Na+ reabsorption.