Distribution and Elimination Jan 10/11

Question 1

Diffusibility-function of the ___

Solubility- function of the ____

Answer 1

Diffusibility- is the function of the membrane

Solubility- is the function of the drug

Question 2

How long something lasts in the body until elimination or until it gets to site of action

Answer 2

Durability

Question 3

3 factors that effect drug concentration

Answer 3

1. body vs SOA
2. Duration
3. Elimination (dif. admin=dif admin)

Question 4

Where will drugs transfer into the bloodstream in oral administration?

Answer 4

Stomach and intestine

Question 5

What type of molecule will move quickly in membrane diffusibility?

Answer 5

Small lipid-soluble drugs

Question 6

What movement do the stomach and intestines allow for lipids and proteins?

Answer 6

out of the bloodstream

Question 7

What role do capillaries play in drug distribution?

Answer 7

• allow for nutrients to transfer
• minimal transfer across membrane
• blood flow affects how things get out of capillaries (think rubber band on arm)
• organs that receive less blood flow also receive less drugs (duh)

Question 8

What is important about the capillaries in the brain?

Answer 8

There is no membrane diffusibility in the capillaries in the brain
-everything is active diffusion- need pumps/transporter proteins