Dissolution, Absorption, and Bioavailability

Question 1

What is dissolution?

Answer 1

process where a medication dissolves in liquid contents of stomach and gut. The pKa of a medication provides guide as to where in GI system dissolution may occur.

Question 2

What state does a drug molecules need to be in the pass from GI tract to bloodstream?

Answer 2

neutral

Question 3

What is bioavailability?

Answer 3

The proportion of medication that enters a patients bloodstream relative to the dose that was administered. Orally is much less than 100%

Question 4

What factors affect bioavailability?

Answer 4

• some medicines exhibit better bioavailability than others when administered orally
• precise form of medicine
• other processes in intestine can reduce, or increase bioavailability. May be degraded by acidic conditions of stomach.