Disorders of the Blood and Lymphatic Systems Flashcards

1
Q

anemia that results from impairment or failure of bone marrow

A

aplastic anemia

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1
Q

common form of megaloblastic anemia that is caused by the malabsorption of vitamin B12 owing to a lack of intrinsic factor (IF) produced in the glands of the gastric mucosa

A

pernicious anemia

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2
Q

most common genetic disorder in the world

A

thalassemia

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3
Q

occurs frequently in people from Mediterranean countries, most common

A

thalassemia beta

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4
Q

deficit or abnormality of clotting factor VIII and is the most common inherited clotting disorder

A

hemophilia A/classic hemophilia

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5
Q

involves a deficit of factor IX

A

hemophilia B/Christmas disease

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6
Q

results from decrease in factor XI

A

hemophilia C/Rosenthal’s hemophilia

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7
Q

disorder that involves excessive bleeding and excessive clotting

A

Disseminated intravascular coagulation (DIC)

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8
Q

a group of inherited or acquired disorders that increase the risk of developing abnormal clots int he veins or arteries

A

thrombophilia

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9
Q

condition in which there is an increased production of erythrocytes, granulocytes, and thrombocytes resulting in increased blood volume and viscosity

A

primary polycythemia/polycythemia vera

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10
Q

neoplastic disorders involving the white blood cells

A

leukemia

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11
Q

3 functions of blood through the body

A
  1. transport oxygen and nutrients to all tissues.
  2. remove waste products of cellular metabolism.
  3. play a critical role in the body’s defenses/immune system, and serve in maintaining body homeostasis.
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12
Q

two types of circulation

A

pulmonary circulation and systemic circulation

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13
Q

smaller branches of arteries that control the amount of blood flowing into capillaries

A

arterioles

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14
Q

very small vessels organized in numerous networks that form the microcirculation

A

capillaries

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15
Q

where is most of the blood during circulation?

A

veins, 70%

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16
Q

another name for veins

A

capacitance vessels

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17
Q

three layers of walls of arteries and veins

A

tunica intima, tunica media, tunica adventitia

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18
Q

inner layer of veins and arteries

A

tunica intima

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19
Q

layer of smooth muscle that controls the diameter and lumen size of the blood vessel, middle layer

A

tunica media

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20
Q

outer connective tissue later that contains elastic and collagen fibers

A

tunica adventitia

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21
Q

tiny blood vessels that supply blood to the tissues of the walls itself

A

vasa vasorum

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22
Q

reflex adjustment in a small area of a tissue or an organ, varies depending on the needs of the cells in the area

A

auto regulation

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23
Q

what controls vasodilation and vasoconstriction in arteriole

A

auto regulation

24
Q

provides the major transport system of the body for essentials

A

blood

25
Q

approximate blood volume in adult

A

5 L

26
Q

proportion of cells in blood, indicates viscosity of blood

A

hematocrit

27
Q

elevated hematocrit would indicate

A

dehydration, excess erythrocytes

28
Q

low hematocrit would indicate

A

blood loss or anemia

29
Q

clear yellowish fluid remaining after the cells have been removed

A

plasma

30
Q

the fluid and solutes remaining after the cells and fibrinogen have been removed from the plasma

A

serum

31
Q

all blood cells originate form

A

red bone marrow

32
Q

where is red bone marrow found

A

flat and irregular bones, ribs, vertebrae, sternum, and pelvis

33
Q

common site for a bone marrow aspiration for biopsy

A

iliac crest

34
Q

pathologic condition of the blood that usually refers to the disorder involving the cellular component of blood

A

dyscrasia

35
Q

biconcave, flexible discs that are non-nucleated when mature and contain hemoglobin

A

erythrocytes

36
Q

where does erythropoietin originate

A

kidneys

37
Q

hormone that stimulates erythrocyte production in the red bone marrow in response to tissue hypoxia

A

erythropoietin

38
Q

erythrocytes are broken down into

A

globin and heme

39
Q

globin is broken down into

A

amino acids, recycled

40
Q

iron returned is returned to the

A

bone marrow and liver

41
Q

excess iron is stored as

A

ferritin or hemosiderin

42
Q

genetic disorder for iron overload, large amounts of hemosiderin accumulating in the liver, heart, and other organ

A

hemochromatosis

43
Q

the balance of the heme component is converted to

A

bilirubin

44
Q

what happens to bilirubin

A

it is conjugated with glucoronide in the liver and excreted in the bile

45
Q

what causes elevated bilirubin levels

A

excessive hemolysis

46
Q

what causes jaundice

A

elevated serum bilirubin levels

47
Q

production of white blood cells

A

leukopoiesis

48
Q

30-40% of the WBCs

A

lymphocytes

49
Q

first to arrive to tissue damage and commence phagocytosis

A

neutrophils

50
Q

migrate from the blood and enter tissue to become mast cells that release histamine and heparin

A

basophils

51
Q

combats the effects of histamine

A

eosinophils

52
Q

increased by allergic reactions and parasitic infections

A

eosinophils

53
Q

enter the tissue to become macrophages

A

monocytes

54
Q

act as phagocytes when damage occurs

A

macrophages

55
Q

indicates the proportions of specific types of WBCs int he blood and assists in diagnosis

A

differential count

56
Q

also called platelets

A

thrombocytes

57
Q
A