Disorders of red cells - iron related disease

Question 1

when does iron deficient erythropoesis occur?

Answer 1

once iron body stores are exhausted

Question 2

3 conditions which lead to iron deficiency?

Answer 2

1. increased demand
2. inability to absorb
3. diet

Question 3

which 2 organs are the cause of inability to absorb iron?

Answer 3

stomach

intestine

Question 4

4 ways iron is lost

Answer 4

1. urine
2. faeces
3. menstruation
4. sweat

Question 5

which 2 groups of people require the most iron?

Answer 5

pregnant + menstruating adolescents

Question 6

4 main effects of iron def

Answer 6

1. pallor
2. sob
3. lassitude
4. fatigue

Question 7

describe levels of MCV in iron def anaemia

Answer 7

low

Question 8

what is the main bleeding disorder which caused IDA?

Answer 8

vW disease

Question 9

2 side effects of parenteral iron administration?

Answer 9

anaphalactic shock

hypersensitivity

Question 10

what is sideroblastic anaemia?

Answer 10

disordered incorporation of iron into the haem within developing erythroblasts

Question 11

2 types of sideroblastic anaemia? which is more common

Answer 11

hereditary

acquired (more common)

Question 12

where is the point mutation in hereditary SBA?

Answer 12

ALA-S

Question 13

treatment of SBA?

Answer 13

Vit b6

Question 14

drug which induces Acquired SBA?

Answer 14

chloramphenicol

Question 15

how does lead accumulation cause Acquired SBA?

Answer 15

in the BM - inhibits haem and globin synthesis

Question 16

why is iron overload an issue?

Answer 16

there is no mechanism to remove excess iron

Question 17

3 causes of iron overload

Answer 17

1. excessive absorption
2. repeated blood transfusion
3. excessive intake

Question 18

main treatment of iron overload?

Answer 18

removing blood (venesection every 1-2 weeks)