Anaemia caused by defects in red cell membrane Flashcards
1
Q
as the RBC ages, what occurs in terms of Na/K levels?
A
increase
2
Q
why does the RBC membrane become more rigid? (2)
A
loss of lipids
changes to cytoskeleton
3
Q
what is extrinsic haemolytic anaemia?
A
Nothing wrong with red cell itself but destroyed by some external pathological process
4
Q
4 types of haemolytic anaemia>?
A
- extrinsic
- intrinsic
- inherited
- acquired
5
Q
2 main types of RBC membrane inherited abnormality
A
- hereditary spherocytosis
2. hereditary elliptocytosis
6
Q
main protein in RBC membrane?
A
spectrin
7
Q
what is the largest organ filter of blood ?
A
spleen
8
Q
when is the spleen palpable?
A
> 14cm
9
Q
which spleen pulp is responsible for monitoring rbc integrity?
A
red
10
Q
5 forms of Hereditary elliptocytosis
A
Common HE Haemolytic HE Hereditary pyropoikilocytosis (HPP) HE with spherocytosis HE with stomatocytosis
11
Q
2 types of cell found in Hereditary pyropoikilocytosis
A
- micro-spherocytes
2. micro- poikilocytes
