Disorders of Appetite Flashcards

1
Q

Define polydipsia, adipsia, anorexia and obesity

A

Polydipsia - excessive thirst or excess drinking
Adipsia - inappropriate lack of thirst with consequent failure to drink in order to correct hyperosmolality
Anorexia - lack or loss of appetite for food
Obesity - abnormal or excessive fat accumulation that presents a risk to health

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2
Q

What causes secondary polydipsia?

A

More common. Medical issues that disrupt any step in osmoregulation or alter ADH can cause secondary polydipsia.

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3
Q

What chronic medical conditions can cause secondary polydipsia?

A
Diabetes insipidus & mellitus
Kidney failure
Conn’s syndrome
Addison's disease
Sickle cell anaemia
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4
Q

What medications can cause secondary polydipsia?

A

Diuretics
Laxatives - Both result in dehydration
Antidepressants

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5
Q

What can cause dehydration and therefore secondary polydipsia?

A
Acute illness
Sweating
Fevers 
Vomiting 
Diarrhoea
Underhydration
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6
Q

What are the 10 symptoms of diabetes insipidus?

A
  1. Always tired
  2. Always hungry
  3. Frequent urination
  4. Blurry vision
  5. Sudden weight loss
  6. Numb or tingling hands and feet
  7. Wounds that won’t heal
  8. Always thirsty
  9. Sexual problems
  10. Vaginal infections
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7
Q

What are causes of primary polydipsia?

A

Mental illness - psychogenic polydipsia (or acquired)
Schizophrenia, Mood disorders - depressionandanxiety, Anorexia, Drug use
Braininjuries
Organic brain damage

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8
Q

What are the consequences of polydipsia?

A

Kidney and bone damage, Headache, Nausea, Cramps, Slow reflexes, Slurred speech, Low energy, Confusion, Seizures

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9
Q

What mental disorders are defined by abnormal eating habits?

A
Binge eating disorder
Anorexia nervosa
Bulimia nervosa
Pica
Rumination syndrome
Avoidant/restrictive food intake disorder
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10
Q

Describe epidemiology of eating disorders

A

Global eating disorderprevalence ↑ed from 3.4% to 7.8% between 2000 and 2018. 70 million people live with eating disorder.

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11
Q

What are the signs of anorexia and mechanism?

A

Signs: Low BMI, continuous weight loss, amenorrhea, halitosis, mood swings, dry hair, skin & hair thinning
Mechanism: Serotonin

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12
Q

How is anorexia defined?

A

Mild: BMI > 17
Moderate: BMI of 16–16.99
Severe: BMI of 15–15.99
Extreme: BMI < 15

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13
Q

How is obesity screened?

A

Height, weight and abdominal girth
Medical history:
Dietary and physical activity patterns, psychosocial factors, weight-gaining medications, familial traits
BMI = kg/m2
BMI of ≥30 or ≥25 + comorbidity or risk factor

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14
Q

How much do diet/exercise contribute to weight loss?

A

Only diet: 8.5%
Only exercise: 2.4%
Diet + Exercise: 10.8%

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15
Q

Who qualifies for surgical treatment of obesity?

A

People with a > BMI 40 or 35+ comorbidities.

Various procedures used but most common are Roux-en-Y gastric bypass & sleeve gastrectomy.

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16
Q

What hormones change due to bariatric surgery?

A
  1. GLP-1 and GLP-2: Stimulate insulin release. Inhibit glucagon release.
  2. Ghrelin: Hunger hormone responsible for NPY activation – initiate appetite
  3. PYY: Responsible for satiety and anorexogenic
17
Q

How do hormones change due to bariatric surgery?

A

Ghrelin reduced so appetite reduced. PYY elevated and GLP-1+2.