Disorders of Adrenal Cortex

Question 1

Constellation of clinical features that result from chronic exposure to excess glucocorticoids of any etiology

Answer 1

Cushing syndrome

Question 2

In an overwhelming majority of patients (that are not taking glucocorticoids) cushings syndrome is caused by

Answer 2

ACTH producing corticrope adenoma

Question 3

Most common cause of Cushing syndrome

Answer 3

Medical use of glucocorticoid

Question 4

Ectopic ACTH production is most frequently caused by tumors most frequently in ?

Answer 4

Lungs

Question 5

Majority of patients with ACTH independent cortisol excess are due to

Answer 5

Cortisol producing adrenal adenoma

Question 6

Which of the following can be an  Ectopic source of ACTH 
A. Non small cell lung CA
B. Papillary thyroid CA
C. Medullary thyroid CA
D. Colon CA

Answer 6

Medullary Thyroids CA
Small cell lung Ca
Pheochromocytoma

Question 7

ACTH producing pituitary adenoma is also called

Answer 7

Cushing’s disease

Question 8

MEN mnemonic

Answer 8

Peter (Pituir) Pan Parades Past Midnight

Men 1
Pituitary
Pancrease
Parathyroid

Men 2
Parathyroid
Pheochromocytoma
Medullary CA

• parathyroid for both

Question 9

Mineralocorticoid action causing hypokalemia, edema and diastolic hypertension is due to what mechanism

Answer 9

Inability of 11B- HSD2 to rapidly inactivate cortisol to cortisone in the kidney

Question 10

Hyperpigmentation of the knuckles, scars or skins areas to increased friction can be observed in
A. Cushings disease
B. Ectopic ACTH syndrome 
C. Adrenocortical adenoma
D. Adrenocortical carcinoma

Answer 10

B. Ectopic ACTH syndrome

Question 11

Possible causes inactivation of dexamethasone

Answer 11

CYP3A4 inducing drugs

CRAP GPS induces rage

Carbamazepine
Rifampin
Alcohol
Phenytoin 
Griseofulvin
Phenobarbital 
Sulfonylurea