Disorders in Pregnancy

Question 1

What prophylactic epileptic treatment should be used in pregnancy?

Answer 1

Lamotrigine

Question 2

What is treatment of seizures in pregnancy?

Answer 2

Magnesium sulphate

Question 3

What happens to thyroid binding globulin in pregnancy?

Answer 3

It increases

Question 4

What increases TBG in pregnancy?

Answer 4

Oestrogen

Question 5

Where is TBG synthesised?

Answer 5

Liver

Question 6

What happens to thyroid hormone T4/T3 in pregnancy?

Answer 6

Both increase

Question 7

What can high T4 cause?

Answer 7

Hyperemesis

Question 8

What happens to TSH in first trimester of pregnancy?

Answer 8

Decreases

Question 9

What causes TSH to decrease?

Answer 9

b-HCG

Question 10

Why does b-HCG decrease TSH?

Answer 10

It is also a glycoprotein and causes negative feedback of the hypophysis

Question 11

What is treatment for someone who is hypothyroid in pregnancy?

Answer 11

Increase L-thyroxine

Question 12

How should hyperthyroidism be treated in pregnancy?

Answer 12

Balance between lowest possible dose and toleration of symptoms

Question 13

What can propylthiouracil and carbimazole cause in the newborn?

Answer 13

Aplasia cutis

Foetal hypothyroidism

Question 14

Why does graves’ disease improve in pregnancy?

Answer 14

Autoimmune conditions all improve in pregnancy

Question 15

What is the differential of a high AFP in pregnancy?

Answer 15

Threatened miscarriage
Multiple pregnancy
Spina bifida
Anencephaly

Question 16

What may be a cause of low AFP and high HCG?

Answer 16

Down’s