Disorders associated with autoimmunity. Flashcards

0
Q

Autoimmune thyroiditis

A

self antigen- thyroglubulin

microsomes

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1
Q

Hyperthyroidism-Graves Disease

A

self antigen- thyroid stimulating antigen on plasma membrane of thyroid cells
S/Sx-

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2
Q

Primary myxedema

A

self antigen- microsomes

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3
Q

Insulin dependent diabetes

A

probable self antigen- islet cells, insulin, insulin receptors on the pancretic cells

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4
Q

Addison disease

A

adrenal gland

probable self antigen- surface antigens on steroid producing cells, microsomes of adrenal cortex.

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5
Q

Premature gonadal failure

A

probable self antigen- interstitial cells: corpus luteum, (ovaries)

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6
Q

Male infertility

A

probable self antigen- surface cells on the spermatozoa

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7
Q

Orchitis

A

self antigen- germinal epithelium

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8
Q

Female infertility

A

probable self antigen- zona pellucida

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9
Q

Idiopathic hypoparathyroidism

A

probable self antigen- surface antigens on cheif cells (epithelial cells of glands) on parathyroid gland.

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10
Q

Partial pituitary deficiency

A

probable self antigen- prolactin producing cells: growth hormone producing cells.

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11
Q

Pemphigus vulgaris

A

probable self antigen-intercellular substances in stratified squamous epithelium

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12
Q

Bullous pemphigoid

A

probable self antigen- basement membrane

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13
Q

Dermatitis herpetiformis

A

IgA- basement membrane

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14
Q

Vitiligo

A

surface antigen on melanocytes.

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15
Q

Polymyositis (dermatomyositis)

A

neuromusclular tissue muscle possible self antigen- nuclear materials, myosin

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16
Q

Multiple sclerosis

A

neural tissue possible self antigen- Unknown.

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17
Q

Myasthenia gravis

A

neuromuscular junction probable self antigen- acetylcholine receptors; striations of skeletal and cardiac muscles

18
Q

Polyneuritis

A

nerve cel probable self antigen-perpheral myelin

19
Q

Rheumatic fever

A

heart probable self antigen- cardiac tissue (subsarcolemmal membrane); cross reaction with group A streptococcal antigen

20
Q

Cardiomyopathy

A

heart possible self antigen- cardiac muscle

21
Q

Postvaccinal or postinfectious encephalitis

A

central nervous system probable self antigen-cns myelin or basic protien.

22
Q

Celiac disease (gluten sensitive enteropathy)

A

intestinal self antigen- gluten

23
Q

Ulcerative colitis

A

colon probable self antigen- mucosal cells

24
Q

Crohn disease

A

iieum prbable self antigen- unknown

25
Q

Pernicious anemia

A

stomach probable self antigen-surface antigen of parietal cells; intrinsic factor

26
Q

Atrophic gastritis

A

stomach probable self antigen-parietal cells

27
Q

Primary biliary cirrhosis

A

liver probable self antigen-mitochondria; cells of the bile duct.

28
Q

Chronic active hepatits

A

liver probable self antigen- surface antigens, nuclei, microsomes mitochondria or hepatocytes, smooth muscle.

29
Q

Sjogren syndrome

A

lacrimal gland probable self antigen- IgG of lacrimal gland, salivary gland, thyroid, and nuclei of cells.

30
Q

Uveitis

A

uveal structure probable self antigen- antigens of the iris, cilliary body and choroid

31
Q

Ankylosing spondylitis

A

connective tissue, joints probable self antigen- saroiliac and spinal apophyseal joint

32
Q

Rhematois arthritis

A

joints probable self antigen- IgG, collagen

33
Q

Systemic lupus erythematosus

A

multiple sites of connective tissue probable self antigens- numerous antigens in nuclei, organelles and extracellular matrix.

34
Q

Mixed connective tissue disease

A

Multiple sites probable self antigen- rna,and numerous other nucleoprotiens

35
Q

Polyarteritis nodosa (necrotizing vasculitis)

A

arterioles probable self antigen- unknown

36
Q

Scleroderma (progressive systemic sclerosis)

A

multiple organs probable self antigen- nuclear antigens; IgG

37
Q

Antiphospholipid antibody syndrome

A

platelet, endothelial cells and trophoblast of placenta proable self antigen-membrane phospholipids, especially phosphatidylserine

38
Q

Immune complex glomerulonephritis-

A

kidney probable self antigen-numerous immune comlexes

39
Q

Goodpasture disease

A

kidney probable self antigen- glomerular basement membrane

lung probable self antigen- septal membrane of alveolus.

40
Q

Idiopathic neutropenia

A

neutrophil probable self antigen- surface antigen on the nuetrophil

41
Q

Idiopathic lymphopenia

A

lymphocytes probable self antigen- surface antigen on the lymphocytes.

42
Q

Autoimmune hemolytic anemia

A

Erythrocytes probable self antigen are the surface antigens of the erythrocyte cells.

43
Q

Autoimmune thrombocytopenic purpura

A

probable self antigen- surface antigen of the platelet