Disorders associated with autoimmunity.

Question 0

Autoimmune thyroiditis

Answer 0

self antigen- thyroglubulin

microsomes

Question 1

Hyperthyroidism-Graves Disease

Answer 1

self antigen- thyroid stimulating antigen on plasma membrane of thyroid cells
S/Sx-

Question 2

Primary myxedema

Answer 2

self antigen- microsomes

Question 3

Insulin dependent diabetes

Answer 3

probable self antigen- islet cells, insulin, insulin receptors on the pancretic cells

Question 4

Addison disease

Answer 4

adrenal gland

probable self antigen- surface antigens on steroid producing cells, microsomes of adrenal cortex.

Question 5

Premature gonadal failure

Answer 5

probable self antigen- interstitial cells: corpus luteum, (ovaries)

Question 6

Male infertility

Answer 6

probable self antigen- surface cells on the spermatozoa

Question 7

Orchitis

Answer 7

self antigen- germinal epithelium

Question 8

Female infertility

Answer 8

probable self antigen- zona pellucida

Question 9

Idiopathic hypoparathyroidism

Answer 9

probable self antigen- surface antigens on cheif cells (epithelial cells of glands) on parathyroid gland.

Question 10

Partial pituitary deficiency

Answer 10

probable self antigen- prolactin producing cells: growth hormone producing cells.

Question 11

Pemphigus vulgaris

Answer 11

probable self antigen-intercellular substances in stratified squamous epithelium

Question 12

Bullous pemphigoid

Answer 12

probable self antigen- basement membrane

Question 13

Dermatitis herpetiformis

Answer 13

IgA- basement membrane

Question 14

Vitiligo

Answer 14

surface antigen on melanocytes.

Question 15

Polymyositis (dermatomyositis)

Answer 15

neuromusclular tissue muscle possible self antigen- nuclear materials, myosin

Question 16

Multiple sclerosis

Answer 16

neural tissue possible self antigen- Unknown.

Question 17

Myasthenia gravis

Answer 17

neuromuscular junction probable self antigen- acetylcholine receptors; striations of skeletal and cardiac muscles

Question 18

Polyneuritis

Answer 18

nerve cel probable self antigen-perpheral myelin

Question 19

Rheumatic fever

Answer 19

heart probable self antigen- cardiac tissue (subsarcolemmal membrane); cross reaction with group A streptococcal antigen

Question 20

Cardiomyopathy

Answer 20

heart possible self antigen- cardiac muscle

Question 21

Postvaccinal or postinfectious encephalitis

Answer 21

central nervous system probable self antigen-cns myelin or basic protien.

Question 22

Celiac disease (gluten sensitive enteropathy)

Answer 22

intestinal self antigen- gluten

Question 23

Ulcerative colitis

Answer 23

colon probable self antigen- mucosal cells

Question 24

Crohn disease

Answer 24

iieum prbable self antigen- unknown

Question 25

Pernicious anemia

Answer 25

stomach probable self antigen-surface antigen of parietal cells; intrinsic factor

Question 26

Atrophic gastritis

Answer 26

stomach probable self antigen-parietal cells

Question 27

Primary biliary cirrhosis

Answer 27

liver probable self antigen-mitochondria; cells of the bile duct.

Question 28

Chronic active hepatits

Answer 28

liver probable self antigen- surface antigens, nuclei, microsomes mitochondria or hepatocytes, smooth muscle.

Question 29

Sjogren syndrome

Answer 29

lacrimal gland probable self antigen- IgG of lacrimal gland, salivary gland, thyroid, and nuclei of cells.

Question 30

Uveitis

Answer 30

uveal structure probable self antigen- antigens of the iris, cilliary body and choroid

Question 31

Ankylosing spondylitis

Answer 31

connective tissue, joints probable self antigen- saroiliac and spinal apophyseal joint

Question 32

Rhematois arthritis

Answer 32

joints probable self antigen- IgG, collagen

Question 33

Systemic lupus erythematosus

Answer 33

multiple sites of connective tissue probable self antigens- numerous antigens in nuclei, organelles and extracellular matrix.

Question 34

Mixed connective tissue disease

Answer 34

Multiple sites probable self antigen- rna,and numerous other nucleoprotiens

Question 35

Polyarteritis nodosa (necrotizing vasculitis)

Answer 35

arterioles probable self antigen- unknown

Question 36

Scleroderma (progressive systemic sclerosis)

Answer 36

multiple organs probable self antigen- nuclear antigens; IgG

Question 37

Antiphospholipid antibody syndrome

Answer 37

platelet, endothelial cells and trophoblast of placenta proable self antigen-membrane phospholipids, especially phosphatidylserine

Question 38

Immune complex glomerulonephritis-

Answer 38

kidney probable self antigen-numerous immune comlexes

Question 39

Goodpasture disease

Answer 39

kidney probable self antigen- glomerular basement membrane | lung probable self antigen- septal membrane of alveolus.

Question 40

Idiopathic neutropenia

Answer 40

neutrophil probable self antigen- surface antigen on the nuetrophil

Question 41

Idiopathic lymphopenia

Answer 41

lymphocytes probable self antigen- surface antigen on the lymphocytes.

Question 42

Autoimmune hemolytic anemia

Answer 42

Erythrocytes probable self antigen are the surface antigens of the erythrocyte cells.

Question 43

Autoimmune thrombocytopenic purpura

Answer 43

probable self antigen- surface antigen of the platelet