Disorders associated with autoimmunity. Flashcards
Autoimmune thyroiditis
self antigen- thyroglubulin
microsomes
Hyperthyroidism-Graves Disease
self antigen- thyroid stimulating antigen on plasma membrane of thyroid cells
S/Sx-
Primary myxedema
self antigen- microsomes
Insulin dependent diabetes
probable self antigen- islet cells, insulin, insulin receptors on the pancretic cells
Addison disease
adrenal gland
probable self antigen- surface antigens on steroid producing cells, microsomes of adrenal cortex.
Premature gonadal failure
probable self antigen- interstitial cells: corpus luteum, (ovaries)
Male infertility
probable self antigen- surface cells on the spermatozoa
Orchitis
self antigen- germinal epithelium
Female infertility
probable self antigen- zona pellucida
Idiopathic hypoparathyroidism
probable self antigen- surface antigens on cheif cells (epithelial cells of glands) on parathyroid gland.
Partial pituitary deficiency
probable self antigen- prolactin producing cells: growth hormone producing cells.
Pemphigus vulgaris
probable self antigen-intercellular substances in stratified squamous epithelium
Bullous pemphigoid
probable self antigen- basement membrane
Dermatitis herpetiformis
IgA- basement membrane
Vitiligo
surface antigen on melanocytes.
Polymyositis (dermatomyositis)
neuromusclular tissue muscle possible self antigen- nuclear materials, myosin
Multiple sclerosis
neural tissue possible self antigen- Unknown.