Disorders associated with autoimmunity. Flashcards
Autoimmune thyroiditis
self antigen- thyroglubulin
microsomes
Hyperthyroidism-Graves Disease
self antigen- thyroid stimulating antigen on plasma membrane of thyroid cells
S/Sx-
Primary myxedema
self antigen- microsomes
Insulin dependent diabetes
probable self antigen- islet cells, insulin, insulin receptors on the pancretic cells
Addison disease
adrenal gland
probable self antigen- surface antigens on steroid producing cells, microsomes of adrenal cortex.
Premature gonadal failure
probable self antigen- interstitial cells: corpus luteum, (ovaries)
Male infertility
probable self antigen- surface cells on the spermatozoa
Orchitis
self antigen- germinal epithelium
Female infertility
probable self antigen- zona pellucida
Idiopathic hypoparathyroidism
probable self antigen- surface antigens on cheif cells (epithelial cells of glands) on parathyroid gland.
Partial pituitary deficiency
probable self antigen- prolactin producing cells: growth hormone producing cells.
Pemphigus vulgaris
probable self antigen-intercellular substances in stratified squamous epithelium
Bullous pemphigoid
probable self antigen- basement membrane
Dermatitis herpetiformis
IgA- basement membrane
Vitiligo
surface antigen on melanocytes.
Polymyositis (dermatomyositis)
neuromusclular tissue muscle possible self antigen- nuclear materials, myosin
Multiple sclerosis
neural tissue possible self antigen- Unknown.
Myasthenia gravis
neuromuscular junction probable self antigen- acetylcholine receptors; striations of skeletal and cardiac muscles
Polyneuritis
nerve cel probable self antigen-perpheral myelin
Rheumatic fever
heart probable self antigen- cardiac tissue (subsarcolemmal membrane); cross reaction with group A streptococcal antigen
Cardiomyopathy
heart possible self antigen- cardiac muscle
Postvaccinal or postinfectious encephalitis
central nervous system probable self antigen-cns myelin or basic protien.
Celiac disease (gluten sensitive enteropathy)
intestinal self antigen- gluten
Ulcerative colitis
colon probable self antigen- mucosal cells
Crohn disease
iieum prbable self antigen- unknown
Pernicious anemia
stomach probable self antigen-surface antigen of parietal cells; intrinsic factor
Atrophic gastritis
stomach probable self antigen-parietal cells
Primary biliary cirrhosis
liver probable self antigen-mitochondria; cells of the bile duct.
Chronic active hepatits
liver probable self antigen- surface antigens, nuclei, microsomes mitochondria or hepatocytes, smooth muscle.
Sjogren syndrome
lacrimal gland probable self antigen- IgG of lacrimal gland, salivary gland, thyroid, and nuclei of cells.
Uveitis
uveal structure probable self antigen- antigens of the iris, cilliary body and choroid
Ankylosing spondylitis
connective tissue, joints probable self antigen- saroiliac and spinal apophyseal joint
Rhematois arthritis
joints probable self antigen- IgG, collagen
Systemic lupus erythematosus
multiple sites of connective tissue probable self antigens- numerous antigens in nuclei, organelles and extracellular matrix.
Mixed connective tissue disease
Multiple sites probable self antigen- rna,and numerous other nucleoprotiens
Polyarteritis nodosa (necrotizing vasculitis)
arterioles probable self antigen- unknown
Scleroderma (progressive systemic sclerosis)
multiple organs probable self antigen- nuclear antigens; IgG
Antiphospholipid antibody syndrome
platelet, endothelial cells and trophoblast of placenta proable self antigen-membrane phospholipids, especially phosphatidylserine
Immune complex glomerulonephritis-
kidney probable self antigen-numerous immune comlexes
Goodpasture disease
kidney probable self antigen- glomerular basement membrane
lung probable self antigen- septal membrane of alveolus.
Idiopathic neutropenia
neutrophil probable self antigen- surface antigen on the nuetrophil
Idiopathic lymphopenia
lymphocytes probable self antigen- surface antigen on the lymphocytes.
Autoimmune hemolytic anemia
Erythrocytes probable self antigen are the surface antigens of the erythrocyte cells.
Autoimmune thrombocytopenic purpura
probable self antigen- surface antigen of the platelet