Disorders Flashcards
Postpartum depression
characterized by depressed affect, anxiety, and poor concentration starting within 4 weeks after delivery
Last 2 weeks to a year or more
Treatment: antidepressants, psychotherapy
Fetal alcohol Syndrome
Related to maternal consumption of alcohol during pregnancy
Fetal alcohol syndrome is most severe
Most preventable cause of intellectual impairment
Often damage to prefrontal cortex leading to: inhibition of planning, self monitoring and regulation and motivation
FAS: short eye openings, flat philtrum, relatively thin upper lip
Microcephaly, cognitive/behavior dysfunction
Growth failure
Confirmed maternal alcohol consumption >4 ounces per day
Infants: sensory and regulatory problems
Toddlers: motor delays, compliance problems, learning difficulties
School-age: regulatory problems persist, difficulty in executive functioning, connecting cause and effect
Adolescence: social understanding impulsivity and poor judgement
Increased risk for disrupted school experiences, alcohol/drug problems, trouble with the law, confinement
Bipolar II disorder
Predominantly depressive episodes but at least one hypomanic episode (not causing significant impairment in daily functioning)
high suicide risk
Treatment: lithium, valproic acid, carbamazepine
Use of antidepressants (especially TCAs) can lead to mania
Conduct
” no one matters but me”
More common in boys
Repetitive and pervasive behavior violating the basic rights of others (physical aggression, destruction of property, theft)
Physically cruel to animals/people, bullies, initiates fights, forced someone into sexual activity, deliberate fire setting, lies, sneaky, disobeys by staying out late at night, has runs away, plays hookie
Angry, and resentful when placed in adult world
Avg-poor school performance
Has a good time with friends
Appears tough/angry/rebellious but actiually feels worthless and doubts self.
Can proceed to antisocial personality behavior
Major depressive disorder
Lasts 6-12 months
5 of 9 of: sleep disturbance, Loss of interest, guilt or feelings of worthlessness, energy loss and fatigue, concentration problems, appetite/weight changes, psychomotor retardation or agitation, suicidal ideations
Depressed mood
Must have anhedonia and self reported depressed mood
Sleep studies: decreased slow wave sleep, decreased REM latency, increased REM early in sleep cycle, increase in total REM sleep, repeated nighttime awakenings, early morning awakening (screen test)
Depressive episode: symptoms for at least 2 weeks
Causes significant impairment in daily functioning
ADHD
Development of structure and function: stepwise but differential progression, connectivity
Behavior: Inattention, hyperactivity, and distractibility
Neuropsychological function: problems with:poor performance, slow reaction time, working memory, set shifting, planning, fluency, response inhibition (can’t inhibit actions toward immediate gratification)
Malfunctions in cognitive control
Anatomically: reduction in prefrontal volume, premotor areas, right hemisphere, basal ganglia, cerebellum, comparable reduction in all four lobes
Reduction in volume of cerebrum especially fronto-striatal and cerebellar regions-rich in dopamine projections
Able to develop inhibitory control as the child grows-ability to suppress information increases from 4-12 years
Treatment: methylphenidate, amphetamines, atomoxetine, behavioral inteventions
Somatic Symptom Disorder
+ Review of Systems Patient (2 GI, 1 sex and 1 pseudoneurologic)
Diagnosis: 1 or more somatic symptoms that are distressing or result in significant disruption of daily life
Excessive thoughts, feelings, or behaviors related to the somatic symptoms
Disproportionate and persistent thoughts about the seriousness of one’s symptoms
Persistently high level of anxiety about health or symptoms
Excessive time and energy devoted to the symptoms or health concerns
Being symptomatic is persistent (> 6 months)
Specify with: pain symptoms, persistent, mild/moderate/severe
Treat with regular scheduled visits with same provider
Limit unnecessary workup and refferals
reassure serious illness has been ruled out
Legitimize symptoms but decrease stress
Promote healthy behavior
Mental health referral once relationship has been established
Functional Neurological Symptom Disorder
Conversion Disorder
NOT aware they are faking it
Diagnosis: One more symptoms that alter motor or sensory function (paralysis, blindness, mutism)
Associated with acute strssor
Clinical findings provide evidence of incompatibility between symptoms and known conditions
Not better explained by another medical condition
Causes clinically significant distress or impairment in social, occupational, or other important areas of functioning
Specify with: type of symptom, acute or chronic, and if associated with or without a psycholgical stressor
Psychological Factors Affecting Other Medical Conditions
Diagnosis: medial symptom or condition is present
Factors have influenced the course of medical condition shown by a close temporal association
Factors interfere with treatment of medical condition
Factors constitute additional well established health risks for the individual
Factors influence the underlying pathophysiology, precipitating or exacerbating symptoms or necessitating medical attention
Specify with: mild moderate, severe, and extreme
Factitious Disorder imposed on self (Münchausen syndrome)
Aware they are faking it-for attention
Falsification of physical or psychological signs or symptoms, or induction of injury or disease
Individual presents himself or herself as ill, impaired, or injured
Evident in the absence of external rewards
Multiple hospital visits with willingness for invasive procedures
Specify: single episode or recurrent episodes
factitious disorder imposed on another
Aware they are faking it-for attention
falsfication of physical or psychological sings or symptoms, induction of injury or disease in another person (form of abuse)
Individual presents another individual to others as ill, impaired, or injured
No obvious external rewards
Specify: single episode or recurrent episodes
Anorexia Nervosa
Presentation: Ammenorrhea, infertility, spontaneous abortions, miscarriages
Constipation, fainting, easy bruising, feeling cold, insomnia, stress fractures, moodiness, loss of interest, lethargy, weakness, hair loss, poor concentration, body checking
Signs: low weight (check accuracy), cardiac (bradycardia, hypotension, arrhythmias), hypothermia, lanugo, orange skin tones, hair loss, dry skin, brittle nails, elevated cholesterol, anemia, osteoporosis, elevated cortisol, decreased T3, peripheral edema, hypophosphatemia, petechiae
Ammenorrhea due to loss of pulsatile GnRH release which cocurs when level of body fat falls below a certain leading to decreased FSH and LH and decreased estrogen
Cardiac atrophy, cardiomyophathy arrhythmia
Hypotension, hypothermia and bradycardia
Criteria: restriction of energy intake relative to requirements
intense fear of gaining weight or becoming fat
Lack of recognition of seriousness of current low body weight
Severity: BMI plus clinical symptomss, degress of functional disability and need for supervision
Mild: 17 Moderate:16-16.99 Severe: 15-15.99 Extreme:
Malingering
Intentional production of feigning of signs or symptoms to achieve personal gain
Multiple vague complaints that do not conform to a known medical condition yet they get better when their objective is obtained
Pretend they are ill with an obvious external incentive
Legal reasons
Autism Spectrum Disorder
Diagnosis: persistent deficits in social communication and interaction across contexts
Restricted, Repetitive patterns of behavior, interest or activities
Symptoms present in early childhood
Symptoms impair and limit daily function
Symptoms not better explained by intellectual disability or global developmental delay
Clinical: Impaired social interactions, impaired ability to communicate, restricted activities and interests, abnormal development soon after birth, 3-6 months abnormal smiling/response to cuddling,
First sign is language in 1st or 2nd year of life
Unusual sensory response to hot, cold, pain, itching etc
Don’t hit normal milestones in saying words or speaking in sentences
Seem aloof, withdrawn, detached
Self stimulation
Impaired social interaction is hallmark of disorder
Displays of love/affection don’t happen
Commitment to routines
70% show ID but may have normal intelligence
Occasional exceptional talent
Primitive reflexes, excess of nonrighthandedness, left brains less often side of language dominance
Epidemiology: Strong genetic heritability
Boys>girls
Fathers >50
Siblings of autistic kids have increased rate of autistic disorder
Mechanism: Chromosomal, monogenic, and epigenetic causes
maternal exposure to child abuse, maternal stress, BPA, maternal obesity, folate deficiency
Teratogens: maternal rubella, valproic acid use, thalidomide, misoprostol
Abnormalities in gyral formation (polymicrogyria), cerebellar vermis, temporal lobes, hippocampal complex and cerebal symmetry
Overall impairment of connectivity in brain networks used for attention, consciousness and self awareness
Assessment: Chromosomal microarray
Rett syndrome
X-linked
Affects mostly females-boys die in utero or shortly afterwards
Small hands and feet
Microcephaly
wringing, putting hands in mouth-hands kept in midline
GI disorders
80% have seizures
No verbal skills
scoliosis, growth failure and constipation
Loss of development, loss of verbal abilities, intellectual disability, ataxia
Body dysmorphic disorder
Preoccupation with one or more perceived defects or flaws in physical appearance that are not observable to others
repetitive behaviors (mirror checking, excessive grooming, skin picking, reassurance seeking) or mental acts (comparing)
may have had plastic surgery but is often dissatisfied with the results
Suicidal ideation and attempts are common
Schizophrenia
2 or more of delusions, hallucinations, disorganized speech, grossly disorganized or catanoic behavior or negative behaviors (flat affect, social withdrawal, lack of motivation lack of speech or thought)
must cause social/occupational dysfunction
Must have 6 months of characteristic symptoms
Mood symptoms are minority of total illness
Types: paranoid, disorganized, catatonic, undiferrentiated (combo of 3)-most common
Clinical: chronic disruption of capacity to think clearly and feel normal emotion
Lifelong pattern of acute psychotic episodes with chronically poor psychosocial adjustment
Symptoms appear in late teens
Cognitive deficits: may appear years before psychotic symptoms
inability to plan/organize, slow verbal learning and memory, poor attention and working memory, loss of executive function, slowing of thought process
Associated with increased ventricular size and reduced GM brain volume
High rate of suicide
Associated with excessive use of cannabis
Course: Childhood-mild minor impairments
Adolescence-nonspecific behavioral changes
Adulthood-development of positive and negative cognitive symptoms
Middle age- unremitting, psoitve and negative cognitive symptoms
Greater risk of death from coronary artery disease or stroke
negative prognostic factors: early and insidious onset, male gender, single marital status, positive family history, obstetric trauma, impaired intellect, comorbid substance abuse
Binge Eating Disorder
Criteria: recurrent episodes of binge eating
Associated with 3 or more of: eating more rapidly than normal, until uncomfortably full, large amount when not physically hungry, alone due to embarrassment, feeling disgusted, distressed or very guilty afterward
Marked distress regarding binge eating
Not associated with recurrent compensatory behavior
Associated symptoms: may have current body image concerns
Onset of dietary restraint AFTER binging begins
May have history of inappropriate compensatory behaviors
Role impairment, decreased satisfaction with life
May become obese
Oppositional
“no one gets to be the boss of me”
Twice as common in boys
Enduring pattern of hostile, defiant behavior toward authority figures in the absence of serious violations of social
Trichotillomania
Recurrent pulling out of one’s hair resulting in hair loss
Repeated attempts to decrease or stop hair pulling
patients who also engage in pica may get trichobezoars
Bulimia Nervosa
Presentation: menstrual irregularity, fatigue, digestive problems, bloating, sore lips, sore throat, mood swings, sleep problems, relationship struggles, difficulty with attention or performance at work
Signs: parotid gland enlargement, weight fluctuation, loss of dental enamel, sores on moth and lips, pallor, injected conjuctiva, callous on knuckles, dark-sunken-or puffy area around eyes, edema, hypokalemia, increased serum amylase, metabolic acidosis (laxatives), metabolic alkalosis (vomiting)
Criteria: recurrent episodes of binge eating
Inappropriate compensatory behaviors (vomiting, diuretics, laxatives, other medication, fasting, excessive exercise)
Occurs at least once a week for 3 months
Self evaluations influenced by body shape and weight
Associated symptoms: anxiety, avoidance, impulse management problems, substance abuse or dependency, PTSD (child sex or physical abuse), bipolar disorder, personality (borderline) disorder
Severity: Frequency of inappropriate compensatory behaviors, other symptoms and level of disability
Mild: 1-3/week Moderate:4-7/week Severe: 8-13/week Extreme:14+
Normal BMI
Paraphilias
Sexual arousal caused by or dependent on less-conventional thoughts or fantasies
Recurrent, intensely sexually arousing fantasies, urges, behaviors
Involve non-human objects suffering, children or non-consenting partners
Sustained for at least 6 months
Causes distress or dysfunction
Types: exhibitionism, voyeruism, sadism, masochism, pedophilia, fetishism, fortteruism, tranvestistic, NOS
Severity:
Relatedness: alone vs clearly negotiated
Requirement: absolute or enhancing
Compuslivity/Impulsivity: out of control vs controlled
Youthful offender commonly have background with neglect/abuse
Exhbitonism more prevalent than rape
Etiology: brain abnormalities: reduction in awareness of/control over unconventional or abnormal urges
evidence of frontal/temporal/limbic involvement, DA regulation
Mental retardation, dementia, seizure disorder, cerebral palsy, ADHD, traumatic brain injury
Loss of access to normative caretaking-develops sense of sense and ability to empathize
Access to sexually arousing material before it is developmentally appropriate
Assessment: some use of penile plethysmography
Careful clinical interview
Often chronic
Vulnerable to stressors that strain self control
Ability to develop empathy and acknowledge others’ rights/autonomy is good prognostic sign
Treatement: megan’s laws (supervision/societal prevention), reduction of sexual drives (SSRI, medroxyprogesterone), treatment of comorbid psychiatric conditions
Cognitive Behavioral training
Psychodynamic therapy: attempting to help patient connect early expereinces and ideas about relationships/sexuality
seasonal affective disorder
clear assoication of symptoms with a time of year (usually winter)
improves in response to full spectrum bright light exposure
Postpartum blues
depressed affect, tearfulness, and fatigue
starts 2-3 days after delivery
Usually resolves within 10 days
Treatment is supportive
Follow up to assess for possible postpartum depression
Premenstrual depressive disorder
worsening symptoms of several days before menses
mood lability, irritability, anger, feeling “keyed up”, depressive symptoms
significant impairment in daily functioning
Dysthymic disorder (persistent depressive disorder)
depressed mood on more days than not for past two years
At least 2 of the depressive symptom cluster