DISLIPIDEMIAS Flashcards

1
Q

El colesterol “malo” es el…

A

LDL

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2
Q

Es la lipoproteína responsable de los triglicéridos…

A

VLDL

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3
Q

Niveles normales de colesterol total en sangre en <19 años

A

<170mg/dl

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4
Q

Niveles normales de colesterol total en sangre en >19 años

A

125-200mg/dl

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5
Q

Como actúan las estatinas?

A

Inhiben la HMG-CoA reductasa

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6
Q

Como actúan los fibratos?

A

Son agonistas de la PPAR-alfa

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7
Q

Que hacen las estatinas para controlar el colesterol?

A

Inhiben la producción de colesterol endógeno y a la vez elevan los receptores para LDL y de HDL

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8
Q

Que hacen los fibratos para controlar el colesterol?

A

Estimulan la PPAR para que así haya cambio de triglicéridos a ac. grasos mediante la lipoporteína lipasa en sangre.

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9
Q

Menciona 3 estatinas:

A
  1. Atorvastatina
  2. Rosuvastatina
  3. Pitavastatina——-NO USA LOS CYP450
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10
Q

Cual es la estatina que no us CYP450 para metabolizarse?

A

Pitavastatina

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11
Q

Efectos adversos de las estatinas:

A

GI

Rabdiolisis, mialgias

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12
Q

Efectos adversos de los fibratos

A

> Riesgo de colelitiasis, GI, disfunción hepática, miopatías

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13
Q

Menciona 3 fibratos:

A
  1. Gemfibrozilo
  2. Fenofibrato
  3. Bezafibrato
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14
Q

Cuales son los Ab monoclonales para tx dislipidemias?

A

Evolocumab

Alirocumab

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