Diseases of the Blood Flashcards
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What are the main functions of the blood?
- transport nutrients
- removal of waste
- trasnport of host defenses
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what are the blood constituents?
- cells
- plasma proteins (albumin and globulin)
- lipids
- nutrients
- water
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anaemia
decreased Hb
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leukopenia
decreased white cell count
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thrombocytopenia
decreased platelets
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pancytopenia
all cells decreased
what occurs if there is multiple changes with regards to anaemia, leukopenia, thrombocytopenia, pancytopenia?
bone marrow failure
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polycythaemia
increased Hb
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leukocytosis
increased WCC
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throbocythaemia
increased platelets
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leukaemia
neoplastic proliferation of white cells, usally disseminated
Intro
Lymhoma
neoplastic proliferation of white cells, usually a solid tumour
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which lineage are RBC (erythrocytes) derived from?
myeloid stem cell
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which lineage are platelets (megakaryocytes) dervied from?
myeloid stem cell
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where are basophil, neutrophil, eosinphil, and monocytes dervied from?
myeloid stem cells
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where are B cells and T cells dervied from?
lymphoid stem cells
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give one example of an acute lymphoid malignancy
acute lymphoblastic leukaemia
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give one example of an acute myeloid malignancy
acute myeloid leukaemia
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give 4 examples of a chronic lymphoid malignancy
- chronic lymphocytic lekaemia
- hodgkin lymphoma
- non-hodgkin lymphoma
- multiple myeloma
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give 2 examples of a chronic myeloid malignancy
- chronic myeloid leukaemia
- myeloproliferative disorders
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what is porphyria?
what are the two main types?
abnormality of haem metabolism
1. hepatic
2. erythropoietic
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