Diseases of Skin and Wounds Flashcards
Abscess/Folliculitis Major Symptoms
Red, itching, burning… may drain pus, blood, or both (pimple, sty, furuncle, carbuncle)
Abscess/Folliculitis Causative Organisms
Staphylococcus Aureus Staphylococcus Epidermidis
Abscess/Folliculitis Type of Pathogen
Bacteria (Gram +)
Abscess/Folliculitis Mode of Transmission
Direct contact/fomites
Abscess/Folliculitis Key Assoications
Staph.. aureus - *More likely cause* of folliculitis; may get “Methicillin Resistant S. Aureus” MRSA Staph… epidermidis - *More predominant* on skin, but *NOT* most likely to cause folliculitis
“Hot Tub” Folliculitis Major Symptoms
small “pimples” on stomach, buttocks, arms and legs
“Hot Tub” Folliculitis Causative Organism
Pseudomonas aeruginosa
“Hot Tub” Folliculitis Type of Pathogen
Bacteria (Gram -)
“Hot Tub” Folliculitis Mode of Transmission
Using a poorly chlorinated hot tub or spa
Staphylococcal Scalded Skin Syndrome (SSSS) Major Symptoms
*Skin peels off in sheets*; Reddening of skin; begins near mouth, spreads over entire body
Staphylococcal Scalded Skin Syndrome (SSSS) Causative Organisms
Staphylococcus aureus
Staphylococcal Scalded Skin Syndrome (SSSS) Type of Pathogen
Bacteria (Gram +)
Staphylococcal Scalded Skin Syndrome (SSSS) Mode of Transmission
Direct contact/fomites
Staphylococcal Scalded Skin Syndrome (SSSS) Key Associations
Can be mistaken for child abuse
Impetigo (Pyoderma) Major Symptoms
Small, flattened red patches on face and limbs; develop into pus filled vesicles that crust (*pyoderma*)
Impetigo (Pyoderma) Causative Organisms
Staphylococcus aureus (80%)
Streptococcus pyogenes (20%)
Impetigo (Pyoderma) Type of Pathogen
Bacteria (Gram +)
Impetigo (Pyoderma) Mode of Transmission
Direct contact/fomites
Impetigo (Pyoderma) Key Associations
Most common in children
Erysipelas Major Symptoms
*Fiery red rash* with sharply defined *raised borders*
Erysipelas Causative Organisms
Streptococcus pyogenes (most cases)
Staphylococcus aureus (occasionally)
Erysipelas Type of Pathogen
Bacteria (Gram +)
Erysipelas Mode of Transmission
Direct contact/fomites
Erysipelas Key Associations
Most common in elderly, peak incidence 60-80
Necrotizing Fasciitis Major Symptoms
*Spreads along fascia*; Destruction of Muscle and fat tissue (*necrosis*), multiple organ failure
Necrotizing Fasciitis Causative Organisms
Streptococcus pyogenes
Necrotizing Fasciitis Type of Pathogen
Bacteria (Gram +)
Necrotizing Fasciitis Mode of Transmission
Person-to-Person Enters through breaks in skin
Necrotizing Fasciitis Key Associations
*aka “flesh eating bacteria”; Emerging Disease*
Acne Major Symptoms
Infection of hair follicle, sebaceous glands
Acne Causative Organism
Propionibacterium acnes
Acne Type of Pathogen
Bacteria (Gram +)
Acne Mode of Transmission
Direct contact
Acne Key Associations
Cystic acne is most severe form
Cat Scratch Disease/Fever Major Symptoms
*Bump or blister* at site of injury, *lymphadenopathy*
Cat Scratch Disease/Fever Causative Organism
Bartonella henselae
Cat Scratch Disease/Fever Type of Pathogen
Bacteria (Gram -)
Cat Scratch Disease/Fever Mode of Transmission
Cat scratches, bites, or licks
Pseudomonas Infection Major Symptoms
Fever, chills, and the production of purulent matter in infected wounds
Pseudomonas Infection Causative Organism
Pseudomonas aeruginosa
Pseudomonas Infection Type of Pathogen
Bacteria (Gram -)
Pseudomonas Infection Mode of Transmission
Opportunistic
Pseudomonas Infection Key Associations
produces a blue-green pigment called *pyocyanin*; infections of severe burns are pervasive
Rocky Mountain Spotted Fever (RMSF) Major Symptoms
*Non-itchy spotted rash* on trunk and appendages; *Including soles and palms; petechiae* Fever, headaches, chills, muscle pain, nausea, vomiting
Rocky Mountain Spotted Fever (RMSF) Causative Organism
Rickettsia ricketsii
Rocky Mountain Spotted Fever (RMSF) Type of Pathogen
Bacteria (Gram -)
Rocky Mountain Spotted Fever (RMSF) Mode of Transmission
Hard ticks vector
Rocky Mountain Spotted Fever (RMSF) Key Associations
Most severe and common Rickettsial illness
Cutaneous Anthrax Major Symptoms
Spreads to form painless, swollen, *black, crusty ulder (eschar)*; Releases anthrax into blood, producing toxemia
Cutaneous Anthrax Causative Organism
Bacillus anthracis
Cutaneous Anthrax Type of Pathogen
Bacteria (Gram +)
Cutaneous Anthrax Mode of Transmission
Direct Contact
Cutaneous Anthrax Key Associations
*Category A Bioterrorist Threat*
Gas Gangrene Major Symptoms
*Foul-smelling; gas bubbles* Intense pain; necrosis; shock, kidney failure, death
Gas Gangrene Causative Organism
Clostridium perfringens
Gas Gangrene Type of Pathogen
Bacteria (Gram +)
Gas Gangrene Mode of Transmission
Fecally contaminated soil/water – traumatic
Gas Gangrene Key Associations
*Rapid treatment is crucial*
Smallpox (aka Variola) Major Symptoms
*Pox lesions* that progress through series of stages
Smallpox (aka Variola) Causative Organism
Smallpox virus (Orthopox virus)
Smallpox (aka Variola) Type of Pathogen
DNA Virus
Smallpox (aka Variola) Mode of Transmission
Primarily through inhalation
Smallpox (aka Variola) Key Associations
*Only* human disease *eradicated worldwide; Category A Bioterrorist threat; BSL-4*
Molluscum Contagiosum Major Symptoms
Raised, *pearl-like waxy* papules
Molluscum Contagiosum Causative Organism
Molluscum Contagiosum virus (Molluscipoxvirus)
Molluscum Contagiosum Type of Pathogen
DNA Virus
Molluscum Contagiosum Mode of Transmission
Direct Contact (sometimes STD)
Molluscum Contagiosum Key Associations
Condoms may not afford protection
Monkeypox Major Symptoms
*Pox lesions* that progress through a series of stages
Monkeypox Causative Organism
Monkeypox virus (orthopoxvirus)
Monkeypox Type of Pathogen
DNA Virus
Monkeypox Mode of Transmission
Primarily through inhalation
Monkeypox Key Associations
*Emerging disease*; less serious than smallpox
Herpes labialis (oral herpes) Major Symptoms
*Blisters on Face/Mouth* recurrent, painful, slow-spreading
Herpes labialis (oral herpes) Causative Organism
Mainly Human Herpes Virus (HHV-1) (aka Herpes Simplex)
Herpes labialis (oral herpes) Type of Pathogen
DNA Virus
Herpes labialis (oral herpes) Mode of Transmission
Close contact with active lesions
Herpes labialis (oral herpes) Key Associations
*Latent* virus usually in *Trigeminal Ganglia*; “above the waist herpes”
Herpetic Whitlow Major Symptoms
*Blisters on Finger* Recurrent, painful, slow spreading
Herpetic Whitlow Causative Organism
Mainly HHV-1 (aka herpes simplex)
Herpetic Whitlow Type of Pathogen
DNA Virus
Herpetic Whitlow Mode of Transmission
Close contact with active lesions
Herpetic Whitlow Key Associations
*Latent virus* usually in *Brachial Ganglia*; “above the waist herpes”
Herpes gladiatorum Major Symptoms
*Blisters anywhere* on body Recurrent, painful, slow-spreading
Herpes gladiatorum Causative Organism
Mainly HHV-1 (aka herpes simplex)
Herpes gladiatorum Type of Pathogen
DNA Virus
Herpes gladiatorum Mode of Transmission
Close contact with active lesions
Herpes gladiatorum Key Associations
*Latent virus* in various ganglia; Associated with *contact sports*
Chickenpox (aka Varicella) Major Symptoms
Extremely *itchy, fluid filled blisters* all over the body
Chickenpox (aka Varicella) Causative Organism
HHV-3 (aka Varicella-Zoster)
Chickenpox (aka Varicella) Type of Pathogen
DNA Virus
Chickenpox (aka Varicella) Mode of Transmission
*Highly infectious disease*- through the respiratory tract or eyes
Chickenpox (aka Varicella) Key Associations
Most often affects children, more serious in adults
Shingles (aka Herpes Zoster) Major Symptoms
*Painful*, blistering skin rash that follows *dermatome (usually unilateral)*
Shingles (aka Herpes Zoster) Causative Organism
HHV-3 (aka Varicella-Zoster)
Shingles (aka Herpes Zoster) Type of Pathogen
DNA Virus
Shingles (aka Herpes Zoster) Mode of Transmission
Reactivated latent virus in *15%* of people who have had chickenpox
Shingles (aka Herpes Zoster) Key Associations
Shingles follow *dermatome; latent virus in spinal DRG*; post-herpetic neuralgia complication of shingles
Warts Major Symptoms
*Benign* epithelial growths on the skin or mucous membranes
Warts Causative Organism
Human Papillomavirus (HPV)
Warts Type of Pathogen
DNA Virus
Warts Mode of Transmission
*Autoinoculation* Direct contact, fomites
Warts Key Associations
Common warts (papilomas): seed warts (fingers, toes), plantar warts (feet), flat warts (trunk, face, elbows, knees)
Rubella (aka German Measels) Major Symptoms
*Rash* of flat, red to pink spots
Rubella (aka German Measels) Causative Organism
Rubella Virus
Rubella (aka German Measels) Type of Pathogen
RNA Virus
Rubella (aka German Measels) Mode of Transmission
Spread in the air via respiratory droplets
Rubella (aka German Measels) Key Associations
In *pregnant women* causes *congenital rubella syndrome*
Measles (aka Rubeola) Major Symptoms
*Koplik’s spots* appear on the mucous membrane of the mouth; *rash* then appears on the head and spread over the body
Measles (aka Rubeola) Causative Organism
Measles virus (Morbillivirus)
Measles (aka Rubeola) Type of Pathogen
RNA Virus
Measles (aka Rubeola) Mode of Transmission
Spread in the air via respiratory droplets *(highly contagious)*
Measles (aka Rubeola) Key Associations
Sometimes causes subacute sclerosing panencephalitis (SSPE); Vaccine has eliminated endemic measles in the US
Erythema infectiosum Major Symptoms
Reddening of the skin *resembles slap, aggravated by sunlight*
Erythema infectiosum Causative Organism
Parvovirus B19
Erythema infectiosum Type of Pathogen
DNA Virus
Erythema infectiosum Mode of Transmission
Spread mostly by droplets; *once the rash is present, the person is usually no longer infectious*
Erythema infectiosum Key Associations
*aka fifth disease, “slapped cheek” syndrome*
Roseola Major Symptoms
*Rose-colored rash*, mononucleosis-like symptoms
Roseola Causative Organism
HHV-6 (aka Roseolovirus)
Roseola Type of Pathogen
DNA Virus
Roseola Mode of Transmission
Person to person, most likely by transfer of oral secretions
Roseola Key Associations
*May* be linked to Multiple Sclerosis; *may* make people more susceptible to AIDS
Piedra Major Symptoms
P. Hortae- *Hard, black, irregular nodules* on the hair shaft T. beiglii- *Soft, grayish-white, irregular nodules* on the hair shaft
Piedra Causative Organism
Piedraia hortae Trichosporon beiglii
Piedra Type of Pathogen
Fungus
Piedra Mode of Transmission
Opportunistic pathogen; often transmitted via shared hair brushes and combs
Piedra Key Associations
P. hortae- *Black Piedra* T. beiglii- *White Piedra*
Pityriasis versicolor Major Symptoms
Hypo- or hyperpigmented patches of scaly skin
Pityriasis versicolor Causative Organism
Malassezia furfur
Pityriasis versicolor Type of Pathogen
Fungus
Pityriasis versicolor Mode of Transmission
Opportunistic pathogen
Pityriasis versicolor Key Associations
takes months to return to normal, identified by green color under UV light
Dermatophytoses (aka “ringworm”) Major Symptoms
Red, raised lesions in specific body region; White/yellow thickening of nails
Dermatophytoses (aka “ringworm”) Causative Organism
Epidermophyton sp. Microsporum sp. Trichopyton sp.
Dermatophytoses (aka “ringworm”) Type of Pathogen
Fungus
Dermatophytoses (aka “ringworm”) Mode of Transmission
Direct Contact/ Fomites
Dermatophytoses (aka “ringworm”) Key Associations
*Tinea Pedis* (athlete’s foot); *Tinea cruris* (jock itch); *Tinea Corporis* (trunk); *Tinea capitis* (head); *Tinea unguium* (onychomycosis)
Sporotrichosis Major Symptoms
*Cutaneous sporotrichosis*: nodular lesions around the infection site; *Lymphocutaneous Sporotrichosis*: secondary lesions occur on the skin along the course of lymphatic vessicles
Sporotrichosis Causative Organism
Sporothrix schenckii
Sporotrichosis Type of Pathogen
Fungus
Sporotrichosis Mode of Transmission
Opportunistic pathogen- thorn prick or splinters allow transmission
Sporotrichosis Key Associations
aka rose-gardener’s disease
Leishmaniasis Major Symptoms
*Cutaneous*: large painless skin lesions; *Mucocutaneous*: skin lesions enlarge to encompass mucous membranes; *Visceral*: parasite is spread by macrophages throughout the body
Leishmaniasis Causative Organism
Leishmania sp. (L. braziliensis, L. donovani, L. tropica)
Leishmaniasis Type of Pathogen
Protozoan
Leishmaniasis Mode of Transmission
Sand fly vector
Leishmaniasis Key Associations
Nicknamed **“Baghdad Boil”**; Visceral Leishmaniasis aka **kala azar**
Scabies Major Symptoms
*Intense itching* and rash of small red bumps at infection site; *often linear*
Scabies Causative Organism
Sarcoptes scabiei
Scabies Type of Pathogen
Mite
Scabies Mode of Transmission
Prolonged bodily contact
Scabies Key Associations
*May* see characteristic **“burrows” or “tunnels”**; Epidemics occur in crowded conditions