Diseases Of Skin Flashcards
What is Christ - Siemen’s Tourian Syndrome?
Type I : Hyponidrotic form of
Ectodermal Dysplasia.
3 H seen here
• Hypohydrosis
• Hypotrichasis
• Hypodontia
Genetic nature of Christ - Siemens Tourian
Syndrome
X- linked recessive disorder.
Only condition where Anodontia is seen is
Ectodermal Dysplasia (although very rarely)
What is Lyon’s hypothesis /
Lyonization
It is a hypothesis for any
✗ -linked recessive
disorder
Genetic nature of Psoriasis
Auto immune skin
disease
What is Koebner’s phenomenon
Aka Isomorphic effect
→ trauma induced lesion
formation
(also seen in lichen Planus but is characteristic of
Psoriasis)
What is AUSPITZ’s Sign
Seen with psoriasis
pinpoint bleeding spots
when silvery white scale is removed.
Which is the sign that shows
pinpoint bleeding spots
when silvery white scale is removed..
And is seen with which condition.
AUSPITZ’s Sign seen in psoriasis
Histopathology of psoriasis shows
test tube shaped rete ridges
Is also seen with:
Gingival fibromatosis and
Drug induced gingival enlargement
-Test tube shape Rete Ridges
Shape seen with
• Psoriasis
• Gingival fibromatosis
• Drug induced gingival
enlargement
What are Munro’s micro abscess
Intra epithelial micro abscess
Seen in psoriasis
What is Psoriasiform lesion
Geographic tonge
• Not related to Psoriasis.
LICHEN PLANUS
• first described by
Erasmus Wilson
Genetic nature of
LICHEN PLANUS
Auto immune
(T- lymphocyte mediated)
What is Grinspan Syndrome
lichen Planers + Diabetes Mellitus + Hypertension
What is Greenspan lesion
Is another name for Oral Hairy leukoplakia.
Not related to lichen Planus
Whicham’s striae /
honitons lace
.. seen ONLY in lichen
Planus.
Whicham’s striae baker.
honitons lace
seen ONLY in lichen
Planus.
honitons lace
Aka
Whicham’s striae
seen ONLY in lichen
Planus.
Which is the most common clinical type of lichen plants
Reticular lichen planus
What is the confirmatory diagnosis of lichen Planus.
DIF
Direct immuno flourescence
(DIF can be done for an
autoimmune disease)
Saw tooth Rete pegs seen in
Hypertrophic lichen Planus
Max-Jacob /Max-Joseph
space seen in
Hypertrophic lichen Planus
between the epithelium and connective tissue
Which type of lichen Planus is a premalignant condition
Erosive lichen planus
(here squamous cell carcinoma eventually develops)
Genetic nature of PEMPHIGUS
’
Autoimmune
cerebriform tongue seen with
Pemphigus vegetans
Histopathology of Pemphigus shows:
Tzank cells
Tzank test is done for diagnosis o
① Pemphigus
② Herpes simplex
DIF (direct immunofluorescence) of Pemphigus shows
IgG in the Intercellular area with Chicken wire pattern or fish net pattern.
Chicken wire pattern or fish net pattern seen in the histopathology of
DIF
(direct immunofluorescence) of Pemphigus
Treatment of Pemphigus
Pulse Therapy
→ DCP pulse therapy
(Dexamethasone cyclophosphamide)
[DCP can cause testicular diseases in males and hence Azathioprine is used instead]
Nikolsky’s sign seen in
Pemphigus
Asboe Hansen sign
Aka and seen in
Nikolsky’s sign seen in Pemphigus
Pemphigus foliaceus
aka brazilian wildfire
brazilian wildfire
brazilian wildfire aka
Pemphigus foliaceus
pemphigus erythematosus
aka
Senear- usher - syndrome
Senear- usher - syndrome aka
pemphigus erythematosus
Hailey Hailey disease aka
familial benign Pemphigus
familial benign Pemphigus aka
Hailey Hailey disease
Genetic nature of PEMPHIGOID
Autoimmune
(Ig G4)
DIF in PEMPHIGOID shows
deposition of IG g and C 3 in the basement membrane zone in Linear pattern.
Stevens Johnson syndrome aka
Erythema Multiforme major
Erythema Multiforme major aka
Stevens Johnson syndrome
Lyell’s disease aka
TENS (toxic epidermal necrolysis)
Target-like/Iris/ bulls eye lesions seen in
Erythema Multiforme
BLOODY ENCRUSTATIONS seen on lips in
Erythema Multiforme
