Diseases of Infancy and Childhood Flashcards
What are the common modes of transmission for TORCHeS infections?
transplacental or via delivery
What does TORCHeS stand for?
Toxoplasma gondii O (other): HIV Rubella CMV Herpes simplex virus 2 e Syphilis
What are the classical neonatal manifestations for a Toxoplasma gondii infection?
chorioretinitis, hydrocephalus, and intracranial calcifications
What is chorioretinitis?
Chorioretinitis (CR) is an inflammatory process that involves the uveal tract of the eye.
What is the mode of transmission for a Toxoplasma gondii infection?
Cat feces or ingestion of undercooked meat
What are some nonspecific signs common to many TORCHeS infections?
hepatosplenomegaly, jaundice, thrombocytopenia, growth retardation
What are the maternal manifestations of a Toxoplasma gondii infection?
Usually asymptomatic; lymphadenopathy (rarely)
What is the common mode of transmission for a CMV infection?
sexual contact, organ transplants
What are the maternal manifestations due to a CMV infection?
Usually asymptomatic; mononucleosis-like illness
Cytomegalovirus:
Viral Family?
Enveloped?
DNA structure?
Herpes Family
Enveloped Virus
DS - linear
Diseases caused by CMV
congenital infection, mononucleosis (negative monospot), pneumonia, retinitis. Infection common in immunosuppressed patients (AIDS retinitis), especially transplant recipients.
CMV infected cells have what sort of characteristic appearance?
“owl’s eye” inclusions.
CMV infections are latent in what type of cells?
Mononuclear cells
What is anasarca?
Anasarca, or extreme generalized edema, is a medical condition characterized by widespread swelling of the skin due to effusion of fluid into the extracellular space.
What is the most common cause of mortality within the first year?
Congenital malformations, deformations, and chromosomal anomalies.
