Diseases Flashcards
What is another name for the Bufo Toad?
Colorado River Toad.
How does the bufo toad produce toxins?
Glands in the skin, largest of which are by the eyes. White, creamy, thick toxin.
What are the toxic principles in bufo toads?
bufagenins and bufotoxins
What is the MOA of bufagenins?
Digitalis-like:
What is the MOA of bufotoxins?
Local anesthetic-like: block sodium channels
Signs of bufo toad toxicity?
Mild: frothy salivation, head shaking, pawing at mouth from local irritation, vomiting or retching
Severe: Convulsions, arrhythmias (various types), dyspnea, death
Treatment for Bufo toad toxicity?
Mild: lavage mouth (toxin can aerosolize so remove animal from area after ravaging)
Severe: treat arrhythmias as standard (atropine for brady, lidocaine for tachy), benzodiazepines for seizures, oxygen support as needed
Full name of Valley Fever
Coccidioides immitis or posadasii
What species are significantly affected by Valley Fever?
All can be affected, only dogs show significant infections usually
When most prone to getting Valley Fever?
Rainy period then a long drought.
How often does dissemination of Valley Fever occur?
20% of the time
If a cat gets Valley Fever what are the signs?
Skin lesions +/- weight loss, fever, inappetence
How often do cats get disseminated disease?
50% but they don’t get it that often to begin with.
Nodules of valley fever have what histological apperance?
Pyogranulomatous and epithelial/giant cells
Diagnosis of valley fever
Enlarged thoracic lymph nodes
Pyogranulomatous nodules with spherules
Confirmative: spherules in tissue
Can also use AGID assays for titers
In tissue what does coccidioides look like?
Spherules
Treatment of valley fever
Fluconazole x 6-12 mo
Amphotericin B best but too toxic