Diseases

Question 1

Hyper-Chylomicronemia:

1. What is increased in blood?
2. Pathophysiology

Answer 1

1. Chylomicrons, TG, Cholesterol
2. Autosomal recessive, lipoprotein lipase deficiency or altered apoliprotein C-II. Causes pancreatitis, hepatosplenomegaly, and eruptive/pruritic xanthomas. Causes creamy layer in supernatant

Question 2

Familial Hyercholesterolemia:

1. What is increased in blood?
2. Pathophysiology

Answer 2

1. LDL, Cholesterol
2. Autosomal dominant. Absent or defective LDL Receptors. Accelerated atherosclerosis, tendon xanthomas, and corneal arcus

Question 3

Hyper-triglyceridemia:

1. What is increased in blood?
2. Pathophysiology

Answer 3

1. VLDL, TG

2. Autosomal dominant. Hepatic overproduction of VLDL. Can cause acute pancreatitis.