Disease Modiyfing Drugs

Question 1

Old approach of dmards
Pyramid 4
Approad

Answer 1

Dmards on top
Predinsolone
Analgesia NSAIDs
Physio ot education rest

Conservative on use of dmards due to the side effects

Question 2

New approach to dmards

3 points

Answer 2

Invert the pyramid
Prescribed within 12 weeks of diagnosis
NSAIDs used in conjunction with

Question 3

Aims of dmards

4

Answer 3

Relieve symptoms
Prevent progression
Prevent disability
Little side effects

Question 4

Name traditional dmard
m————–
How it works
Side effects

Answer 4

Methotrexate
Forlico acid antagonist
Inhibits dihydroforlate reductase reducing the production of folic acid

Se rapid turn over cells
Bone marrow hair loss mouth sores nausea due to it

Fatigue due to Gi disturbances

Question 5

Traditional dmard
C——–
How
Se

Answer 5

Inhibits helper T cells powerful immunosuppressive
No effect on inflammation

Se: neprotoxicity
Hepatatocity
Hypertension

Question 6

Biological dmards

4 points on them

Answer 6

Quicker acting 
Use when traditional don't work
Replicates immune system 
Injection so inconvient
Cost more

Question 7

Type of biological dmards

2

Answer 7

Anakinra - SC injection daily
Injection site, URTI, low wbc, pneomia

Infliximab - Iv infusion 8 weeks
Same but anaphylaxis ms nerve disorders

Question 8

Use for dmarmds

5

Answer 8

First line RA
Pa
Sle
Cancer 
Inflammatory bowel disease