Disease Modifying Anti-Rheumatic Drugs (DMARDS) Flashcards
1
Q
methotrexate
A
- fastest DMARD
- causes adenosine efflux which produces anti-inflammatory effect
- risk of ulcers and fetal death
2
Q
hydroxychloroquine
A
- accumulates in lysosomes
- limits the proper presentation of antigens by changing the interaction with MHC II
- safe to use in pregnancy
- risk of retinal damage
3
Q
sulfasalazine
A
- Used alone or with hydroxychloroquine and/or methotrexate
- risk of GI effects, sulfa rxn
4
Q
leflunomide
A
- inhibits dihydroorotate dehydrogenase
- inhibits T cell proliferation
5
Q
d
A
d
6
Q
What are the three TNF inhibitors?
What are adverse rxn?
A
Adalimumab
Etanercept
Infliximab
Severe allergic rxn
7
Q
Abatacept
A
Prevent CD28 from binding to CD80/CD86
8
Q
What are the Biologic DMARD
DON’T COMBINE, Use with non-biologic DMARD
A
Rituximab Abatacept Anakinra TNF Antagonist (Adalimumab, Etanercept, Infliximab) Tocilizumab Tofacitinib
RAATTT
9
Q
tocilizumab
A
- inhibits IL-6 receptor
- Risk of URI infection
10
Q
tofacitinib
A
- JAK3 antagonist
- directly inhibits the production of IL-17, IFNγ, T cell proliferation
11
Q
anakinra
A
IL-1 receptor antagonist
