Disease Drug Therapy

Question 1

schizophrenia - first line

Answer 1

antipsychotics: dopamine receptor antagonists

group 1 atypicals: risperidone, olanzapine, quetiapine

Question 2

schizophrenia - second line

Answer 2

first-generation atypicals: haloperidol, chlorpromazine

has increased extrapyramidal symptoms

these treat positive symptoms better

Question 3

schizophrenia - refractory

Answer 3

clozapine (group 1 atypical)

tried after 2-6 weeks (more like six weeks)

Question 4

MDD - first line

Answer 4

SSRIs: used in mild to moderate

Question 5

MDD - second line

Answer 5

SNRIs, bupropion, and mirtazapine

Question 6

MDD - third line

Answer 6

TCAs and MAOIs

Question 7

Indications of typical first gen

Answer 7

psychosis, schizophrenia

Question 8

Indications of atypical second-gen

Answer 8

first-line for psychotic disorders

clozapine (atypical group 1) for refractory

Question 9

Risperidone (group 1 atypicals) and Ziprasidone (group 2 atypicals) indications

Answer 9

schizophrenia, bipolar, psychosis

Question 10

aripiprazole indications

Answer 10

psychotic disorders

Question 11

lithium indications

Answer 11

bipolar disorders: acute mania

Question 12

valproate and carbamazepine

Answer 12

anticonvulsants that suppress impulsive and aggressive behavior

Question 13

SSRI indications

Answer 13

first-line for depression and anxiety disorders

Question 14

SNRI indications

Answer 14

may be used as first-line, esp. in those with significant fatigue or pain syndromes with depression

(like duloxetine)

Question 15

TCA indications

Answer 15

depression
insomnia
diabetic neuropathic pain
post-herpetic neuralgia
migraine
urge incontinence

Question 16

mirtazapine indication

Answer 16

depression

less sexual dysfunction S/E

Question 17

bupropion indication

Answer 17

depression –> less GI/sexual dysfunction as compared to SSRI

smoking cessation

Question 18

MAOIs indications

Answer 18

refractory depression

many types of anxiety and affective disorders

Question 19

trazodone indications

Answer 19

antidepressant, anti-anxiety, and hypnotic effects

Question 20

priapism side effect

Answer 20

trazodone

Question 21

anticholinergic side effects

Answer 21

TCAs

mirtazapine

Question 22

hypertensive crisis S/E

Answer 22

MAOIs

Question 23

agranulocytosis S/E

Answer 23

clozapine

mirtazapine

Question 24

seizure threshold lowered

Answer 24

bupropion

Question 25

bipolar I - first line

Answer 25

lithium as a mood stabilizer

or valproic acid or carbamazepine

Question 26

bipolar I - second line

Answer 26

second-gen antipsychotics: olanzapine

haloperidol or benzo add for psychosis/agitation

Question 27

bipolar II - first line

Answer 27

acute mania: mood stabilizers like lithium, valproate, or second-gen antipsychotics

depression: lithium, valproate, carbamazepine
mixed: atypical antipsychotics

Question 28

panic attack treatment

Answer 28

benzos like lorazepam or alprazolam

Question 29

panic disorders

Answer 29

SSRIs like paroxetine, sertraline, fluoxetine

acute attacks: benzos like alprazolam, clonazepam

Question 30

GAD treatment

Answer 30

SSRIs like paroxetine or escitalopram

OR

SNRIs: venlafaxine

Question 31

GAD second line

Answer 31

buspirone (non-benzo anti-anxiety)

Question 32

OCD treatment

Answer 32

SSRIs like fluoxetine, sertraline, paroxetine

OR

TCAs

OR

SNRIs