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HLA > Disease Associations > Flashcards

Disease Associations Flashcards

1
Q

21 hydroxylase deficiency (CAH) linked to

A

HLA-B8, DR3 haplotype

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2
Q

Hemochromatosis linked to

A

HLA-A3

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3
Q

Narcolepsy

A

HLA-DQB1*06:02

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4
Q

RR of Narcolepsy when HLA-DQB1*06:02 is present

A

200

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5
Q

Celiac disease (primary association)

A

DQA105:01, DQB102:01

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6
Q

Celiac disease (secondary association)

A

DQA103, DQB103:02 (8)

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7
Q

Rheumatoid arthritis (primary association)

A

DRB1*04:01, 04:04, 04:05

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8
Q

Rheumatoid arthritis (secondary association)

A

DRB101:01; DRB114:02

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9
Q

Type 1 Insulin Dependent Diabetes (primary association)

A

DQB1*03:02 (8)

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10
Q

RR of Type 1 Insulin Dependent Diabetes (primary association)

A

8

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11
Q

Type 1 Insulin Dependent Diabetes (secondary association) and relative risk

A

DQB102:01 (RR=4); DQB103:03 (RR=4)

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12
Q

Type 1 Insulin Dependent Diabetes synergistic combination and RR

A

DQB103:02/DQB102:01 (RR=20)

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13
Q

Protective against Type 1 Insulin Dependent Diabetes

A

DQB1*06:02

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14
Q

Ankylosing spondylitis (primary association)

A

B*27:02, 27:04, 27:05, 27:07

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15
Q

B27 alleles that are not associated with Ankylosing spondylitis

A

B*27:06, 27:09

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16
Q

Ankylosing spondylitis (lesser association)

A

B*40:01

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17
Q

Behcets Disease (primary association)

A

HLA-B51

18
Q

Odds Ratio of Behcets disease in presence of B51

A

5.78

19
Q

Behcets Disease (lesser associations)

A

B15, B27, B57, A26

20
Q

Protective allele against HIV

A

HLA-B*57:01

21
Q

Allele associated with slow HIV progression

A

B27

22
Q

Allele associated with rapid HIV progression

A

B35:02 and B35:03; not most common B*35:01

23
Q

Higher expression of HLA-____ is HIV protective but associated with higher viral mutation rates

A

C

24
Q

HIV-1 Nef protein selectively downregulates HLA-___ and ____ but spares ____

A

A;B;C

25
Q

Drug reaction to Carbamazepine (OR)

A

B15:02/A31:01 (1000)

26
Q

Drug reaction to abacavir/flucloxacillin (OR)

A

B*57:01 (OR for flucloxacillin induced liver injury = 80)

27
Q

Drug reaction to statins

A

DRB1*11:01

28
Q

Drug reaction aspirin

A

DRB113:02/DQB106:09

29
Q

Drug reaction to Allopurinol (OR)

A

B*58:01 (800)

30
Q

Drug reaction to Ticolopidine

A

A33:03/DQB106:04

31
Q

Drug reaction to Lamotrigine

A

A*68:01

32
Q

Drug reaction to cold medicines

A

A02:06/B44:03

33
Q

Drug reaction to Dapsone

A

B*13:01

34
Q

Drug reaction to Phenytoin

A

B15:02/B56:02

35
Q

Drug reaction to Clozapine

A

DQB1*05:02

36
Q

Drug reaction Nevirapine

A

C04:01/08(01)

37
Q

Multiple Sclerosis

A

HLA-DRB1*15:01

38
Q

Psoriasis

A

C*06:02

39
Q

Subacute thyroiditis

A

B35

40
Q

Juvenile rheumatoid arthritis

A

DR8

41
Q

Graves disease

A

DR3

HLA (11 decks)

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