Disease Associations

Question 1

21 hydroxylase deficiency (CAH) linked to

Answer 1

HLA-B8, DR3 haplotype

Question 2

Hemochromatosis linked to

Answer 2

HLA-A3

Question 3

Narcolepsy

Answer 3

HLA-DQB1*06:02

Question 4

RR of Narcolepsy when HLA-DQB1*06:02 is present

Answer 4

200

Question 5

Celiac disease (primary association)

Answer 5

DQA105:01, DQB102:01

Question 6

Celiac disease (secondary association)

Answer 6

DQA103, DQB103:02 (8)

Question 7

Rheumatoid arthritis (primary association)

Answer 7

DRB1*04:01, 04:04, 04:05

Question 8

Rheumatoid arthritis (secondary association)

Answer 8

DRB101:01; DRB114:02

Question 9

Type 1 Insulin Dependent Diabetes (primary association)

Answer 9

DQB1*03:02 (8)

Question 10

RR of Type 1 Insulin Dependent Diabetes (primary association)

Answer 10

8

Question 11

Type 1 Insulin Dependent Diabetes (secondary association) and relative risk

Answer 11

DQB102:01 (RR=4); DQB103:03 (RR=4)

Question 12

Type 1 Insulin Dependent Diabetes synergistic combination and RR

Answer 12

DQB103:02/DQB102:01 (RR=20)

Question 13

Protective against Type 1 Insulin Dependent Diabetes

Answer 13

DQB1*06:02

Question 14

Ankylosing spondylitis (primary association)

Answer 14

B*27:02, 27:04, 27:05, 27:07

Question 15

B27 alleles that are not associated with Ankylosing spondylitis

Answer 15

B*27:06, 27:09

Question 16

Ankylosing spondylitis (lesser association)

Answer 16

B*40:01

Question 17

Behcets Disease (primary association)

Answer 17

HLA-B51

Question 18

Odds Ratio of Behcets disease in presence of B51

Answer 18

5.78

Question 19

Behcets Disease (lesser associations)

Answer 19

B15, B27, B57, A26

Question 20

Protective allele against HIV

Answer 20

HLA-B*57:01

Question 21

Allele associated with slow HIV progression

Answer 21

B27

Question 22

Allele associated with rapid HIV progression

Answer 22

B35:02 and B35:03; not most common B*35:01

Question 23

Higher expression of HLA-____ is HIV protective but associated with higher viral mutation rates

Answer 23

C

Question 24

HIV-1 Nef protein selectively downregulates HLA-___ and ____ but spares ____

Answer 24

A;B;C

Question 25

Drug reaction to Carbamazepine (OR)

Answer 25

B15:02/A31:01 (1000)

Question 26

Drug reaction to abacavir/flucloxacillin (OR)

Answer 26

B*57:01 (OR for flucloxacillin induced liver injury = 80)

Question 27

Drug reaction to statins

Answer 27

DRB1*11:01

Question 28

Drug reaction aspirin

Answer 28

DRB113:02/DQB106:09

Question 29

Drug reaction to Allopurinol (OR)

Answer 29

B*58:01 (800)

Question 30

Drug reaction to Ticolopidine

Answer 30

A33:03/DQB106:04

Question 31

Drug reaction to Lamotrigine

Answer 31

A*68:01

Question 32

Drug reaction to cold medicines

Answer 32

A02:06/B44:03

Question 33

Drug reaction to Dapsone

Answer 33

B*13:01

Question 34

Drug reaction to Phenytoin

Answer 34

B15:02/B56:02

Question 35

Drug reaction to Clozapine

Answer 35

DQB1*05:02

Question 36

Drug reaction Nevirapine

Answer 36

C04:01/08(01)

Question 37

Multiple Sclerosis

Answer 37

HLA-DRB1*15:01

Question 38

Psoriasis

Answer 38

C*06:02

Question 39

Subacute thyroiditis

Answer 39

B35

Question 40

Juvenile rheumatoid arthritis

Answer 40

DR8

Question 41

Graves disease

Answer 41

DR3