Direct oral anticoagulants Flashcards
1
Q
how do DOACs work
A
directly target the activity of thrombin and factor Xa
2
Q
give a direct thrombin inihibitor
A
dabigatran
3
Q
give a direct factor Xa inhibitor
A
apixaban
rivaroxaban
edoxaban
4
Q
give some advantages of using a DOAC over warfarin
A
rapid onset and offset
fewer drug interaction
fixed dosing
no routine monitoring
5
Q
what are the potential disadvantages of using a DOAC
A
UNSAFE in advanced renal impairemnt
not as effect as warfarin for metallic heart valves
lack of specific antidote for reversal of anticoagulation
6
Q
what are the main indications for a DOAC
A
VTE prophylaxis and treatment
ACS
AF
