Coagulation screen Flashcards
1
Q
what tests are included as part of the coagulation screen
A
1) prothrombin time
2) activated partial prothrombin time
3) fibrinogen concentration
2
Q
what is the prothombin time a test of
A
extrinsic and common pathway
3
Q
what can cause a prolonged prothrombin time
A
- warfarin use (vitamin K deficiency)
- severe liver disease
- DIC
- deficiency/inhibtiors of factors 2, 7, 10, fibrinogen
4
Q
what is the prothrombin time
A
the time taken for a sample of blood to clot after tissue factor and calcium are added
5
Q
what is the APTT a test of
A
intrinsic and common pathway
6
Q
what can cause a prolonged APTT
A
- mild liver disease
- heparin therapy
- lupus antibodies
- deficiency of factors 2, 5, 7, 9, 10, 12, fibrinogen
- DIC
7
Q
what can cause raised fibrinogen
A
acute phase response
8
Q
what can cause low fibrinogen
A
severe sepsis, DIC, rare congenital issues
