Direct Acting Cholinergic Receptor Agonists

Question 1

Acetylcholine (Miochol)

Answer 1

Cholinergic agonist: ESTER

-intraocular use for miosis during surgery

Question 2

Carbachol (Isoptocarbachol)

Answer 2

Cholinergic agonist: ESTER

-intraocular use for miosis during surgery, glaucoma

Question 3

Methacholine (Provocholine)

Answer 3

Cholinergic agonist: ESTER

Question 4

Bethanechol (Urecholine)

Answer 4

Muscarinic agonist: ESTER

-Urinary retention, post operative ileus

Question 5

(+) - Muscarine

Answer 5

Cholinergic agonist: Alkaloid + Synthetic Analog

Question 6

Nicotine (Nicorette)

Answer 6

Cholinergic agonist: Alkaloid + Synthetic Analog

• dibasic
• nicotinic receptors less stereoselective

Question 7

Pilocarpine (isoptocarpine)

Answer 7

Muscarinic agonist: Alkaloid + Synthetic Analog

-Glaucoma

Question 8

Varenicline tartrate (Chantix)

Answer 8

a4b2 Nicotinic receptor partial agonist

• activates nicotinic receptor much less than nicotine; blocks nicotine from binding
• Side effects: GI related issues (nausea, constipation, gas, vomiting); altered dreams
• smoking cessation