Additional Drugs

Question 1

Reserpine (Serpasil)

Answer 1

 Indole alkaloid obtained from the root of Rauwolfia serpentina
 Block vesicular monoamine transporters
 Deplete vesicular pool of NE
 Slow onset of action
 Sustained effect (weeks)
 Used in the treatment of hypertension
 May precipitate depression

Question 2

Bretylium Tosylate (Bretylol)

Answer 2

 Aromatic quaternary ammonium
 Precise mechanism unknown
 Displace and release NE and prevent further release (depletion)
 Local anesthetic
 Administered: Parenteral
 Uses: Antiarrhythmic (ventricular fibrillation)