Direct-acting ACh receptor agonists 2 (plant alkaloids and synthetic drugs)

Question 1

Plant alkaloids (3 drugs)

Answer 1

Muscarine
Nicotine
Pilocarpine

Question 2

Nicotine - indications

Answer 2

Smoking cessation

Question 3

Pilocarpine has affinity for which receptors?

Answer 3

Both, but greater affinity for muscarinic receptors

Question 4

Pilocarpine - indications

Answer 4

Chronic open-angle glaucoma (2nd line).
Acute angle-closure glaucoma.
Xerostomia.

Question 5

Pilocarpine - mechanism for decreasing intraocular pressure

Answer 5

Increases the outflow of aqueous humor

Question 6

Pilocarpine - side effects

Answer 6

Decreased night vision

Difficulty focusing on distant objects

Question 7

Synthetic direct-acting ACh receptor agonists (2 drugs)

Answer 7

Cevimeline

Varenicline

Question 8

Cevimeline - indications

Answer 8

Dry mouth (Sjögren / after radiation)

Question 9

Cevimeline - adverse effects

Answer 9

Sweating
Nausea
Visual disturbances

Question 10

Varenicline - affinity for which receptors

Answer 10

Nicotinic receptors in brain (partial agonists)

Question 11

Varenicline - indications

Answer 11

Smoking cessation.