Digestive System Flashcards

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1
Q

How are the digestive system organs divided?

A
  • Alimentary canal: GI tract/gut
    o Muscular tube from mouth to anus
    o Digests and absorbs food
  • Accessory Digestive Organs
    o Produce secretions to digest food
    o Teeth, tongue, salivary glands, gallbladder, liver, pancreas
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2
Q

What happens/where during the digestive process?

A
  • Ingestion + propulsion –> mechanical breakdown –> chemical digestion –> absorption –> defecation
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3
Q

Explain each digestive process

A
  • Propulsion
    o Swallowing
    o Peristalsis – involuntary; contraction/relaxation of organ walls
  • Mechanical breakdown
    o Chewing
    o Mixing
    o Churning
    o Segmentation – constriction of small intestine + digestive juices
  • Chemical Digestion – breakdown into chemical blocks with enzymes
  • Absorption – end products (vitamins, minerals, and water) from lumen through mucosal cells into blood or lymph
  • Defecation – get rid of indigestible solid wastes
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4
Q

What controls digestive activity? What do the receptors respond to?

A

via mechano and chemoreceptors

  • Mechano and chemoreceptors respond to:
    o Stretching of organ from food
    o Presence of substrates and end products
    o Osmolarity
    o pH
  • receptors initiate reflexes that:
    o activate or inhibit glands
    o stim smooth muscle to mix contents and move them
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5
Q

What relationship does the GI have with the Peritoneum?

A
  • Peritoneum – serous membrane of ab cavity
    o Visceral – external of digestive organs
    o Parietal – lines entire body wall
  • Peritoneal cavity – fluid filled space between the two
    o Lubes
  • Mesentery – double layer of Peritoneum
    o Extends organs from body wall
    o Vascular and nerve supplier to visceral
    o Holds organs in place
    o Stores fat
  • Peritoneal Organs – surrounded by peritoneum: stomach
  • Retroperitoneal organs – outside the peritoneum: pancreas, duodenum, large intestine
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6
Q

What provides blood to the digestive system?

A
  • Splanchnic Circulation – arteries branch off aorta to serve digestive organs
    o Celiac trunk branches supply stomach and liver
    o Mesenteric arteries – supply small and large intestines
  • Hepatic portal
    o Collects nutrient rich venous blood from: stomach, small/large intestines –> liver for metabolic processing and storage via hepatic portal vein
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7
Q

What are the 4 layers of the alimentary canal?

A
  • Mucosa
    o Secretes mucous, digestive enzymes, absorbs end products into blood, protects bad bacteria
  • Submucosa
    o Supply blood vessels and nerve fibers
  • Muscularis externa
    o Smooth muscle = segmentation and peristalsis (sphincters)
  • Serosa
    o Holds everything together; visceral peritoneum
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8
Q

What structures make up the oral cavity?

A
  • Buccal cavity – stratified squamous epithelium with keratinization for protection
  • Teeth – mastication
  • Palate –
    o hard palate – anterior; rigid bone for chewing
    o soft palate – posterior; skeletal muscles closing nasopharynx during swallowing + uvula
  • tongue – skeletal muscle
    o mixes food with saliva to compact mass (Bolus)
    o papillae either contain taste buds or provide friction
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9
Q

What are the different salivary glands?

A
  • Major salivary glands – produce most saliva  presence of food and though of food
    o Parotid glands
    Mumps – inflammation caused by virus and common in childhood
    o Submandibular glands
    o Sublingual glands
  • Within glands, saliva is secreted from?
    o Serous cells – watery secretion with enzymes
    o Mucous – mucus
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10
Q

What is the purpose of saliva and what is it made up of?

A
  • Functions
    o Cleaning
    o Dissolve foods
    o Moisten food into bolus
    o Contain enzymes for chemical breakdown of starch
  • What is it made of?
    o Electrolytes
    o Digestive enzymes:
     Salivary amylase – breaks down starch
     Lingual lipase – breaks lipids
    o Protein: mucin, lysosome, defensin, lgA
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11
Q

What makes up the Pharynx?

A
  • Throat
  • Oropharynx –> laryngopharynx
  • Squamous epithelium and mucus
  • Two skeletal muscles – propel food into esophagus
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12
Q

What makes up the esophagus?

A
  • Muscular tube from laryngopharynx to stomach
    o Change from skeletal to smooth
  • Upper esophageal sphincter  gastroesophageal sphincter
  • Joins stomach at cardiac orifice
  • What does mucus do?
    o In gastroesophageal sphincter protects esophagus from reflux of stomach acid
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13
Q

What happens during Deglutition (swallowing)?

A
  • Highly coordinated with tongue + soft palate + etc
  • Buccal Phase
    o Mouth and voluntary
    o Tongue pressed against roof, bolus is forced into oropharynx
    o Swallowing past uvula is involuntary
  • Pharyngeal-esophageal phase
    o Involuntary
    o All routes sealed except digestive tract
    o Peristalsis moves food
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14
Q

What digestive processes are the Mouth and its accessory organs involved in?

A
  • Ingestion
  • Mechanical breakdown
  • Chemical digestion
  • Propulsion
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15
Q

What is the stomach and what occurs there?

A
  • Smooth muscle storage tank
  • Chemical breakdown of proteins + food converted chyme
  • 50ml when empty or 4L when full
  • Vomiting (emesis) – stretching or irritant
  • Collapses into folds when empty (rugae) – sound
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16
Q

What structures exist within the stomach?

A
  • Cardia – opening
  • Fundus – dome at top
  • Body – midportion
  • Pyloric part – distal region
    o Pyloric antrum + canal
  • Pyloric sphincter – end  duodenum
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17
Q

What are the different layers of the stomach?

A
  • Mucosa
  • Submucosa
  • Muscularis externa
  • Serosa
18
Q

What makes up the epithelial lining?

A
  • Surface mucous cells – alkaline coat to protect stomach
  • Gastric pits – gastric juice
19
Q

What are the different types of stomach gland cells?

A
  • Mucous neck cells – acidic mucus
  • Parietal – secret HCL and intrinsic factor
  • Chief cell – pepsinogen – protein producing enzyme
  • Enteroendocrine cells – secretes chemical messengers
    o Gastrin (G cells) – stimulate parietal cells to HCL(hydrochloric acid) secretion + small intestine contraction
    o Somatostatin – D cells that influence digestive organs
     Stomach – inhibits gastric secretion
     Pancreas – inhibits secretion of insulin and glucagon
20
Q

How does the mucosal barrier of the stomach lining work?

A
  • Mucosal barrier to prevent gastric juice from eating itself
    o Bicarbonate rich mucus
    o Epithelial cells + tight junctions
    o Epithelial lining is rebirthed every 3-6 days
  • Gastric ulcer – erosion
21
Q

What structures of the stomach wall enhance digestion?

A
  • Muscular layer
  • Mucosa epithelial lining = stomach gland cells
22
Q

How does the stomach regulate gastric secretion?

A

o Phase 1 Cephalic (reflex) – before food is eaten
 Few mins
 Pavlonian + smelling/seeing food
 Stimulation –> sight and thought + taste and smell
 Inhibit –> loss of appetite + depression

o Phase 2 Gastric Phase – food enters stomach
 2/3 gastric juice released
 Stimulation –> stretching + food chemicals
 Inhibit –>excess acidity + emotional stress

o Phase 3 Intestinal
 Short stim –> inhibit gastric secretion
 Enterogastric reflex – declines gastric secretory to protect small intestine
 Stimulation –> partially digested food
 Inhibit –> presence of chyme + food

23
Q

What is the enteric nervous system?

A
  • Controls digestion
  • Communicates with CNS, para with Vagus nerve and sympa with collateral ganglia
  • Separate with reflex activity
    o Motor neurons controls peristalsis and churning
    o Neurons control secretion of enzymes
24
Q

How does Gastric contractile activity work?

A
  • Peristalsis waves pylorus at 3/min
    o Controlled by cells of Cajal (pacemaker)
    o Propulsion  grinding  retropulsion
25
Q

What is the essential stomach function?

A
  • Intrinsic factor – absorption of B12 for red blood cell production
26
Q

What makes up the small intestine?

A
  • Pyloric sphincter to ileocecal valve
    o Duodenum
     Where food transfers from stomach
     Hepatopancreatic ampulla – bile duct and pancreatic duct empty into duo
    o Jejunum
     8’
    o Ileum
     12’
     Thick mesentery for both
27
Q

What exists within the small intestine (micro)

A
  • Absorbs nutrients
  • Circular folds – deep mucosa/sub
    o Force chyme to spiral through lumen slowing movement
  • Villi – small extensions
    o Epithelium = absorptive cells – electrolytes and nutrients
    o Intestinal crypts – secrete intestinal juice and enteroendocrine cells that make enterogastrones
  • Microvilli – tiny extensions of absorptive
    o Brush border enzymes to digest carbs and small proteins
28
Q

How is it made and what makes up intestinal juice?

A
  • Intestinal glands secrete 1-2 L daily
  • Slightly alkaline, largely water + mucus
  • Enzyme poor and in response to irritation of mucosa
29
Q

What makes up the liver?

A
  • 4 lobes
  • Hepatic artery, hepatic portal vein enter liver via porta hepatis
30
Q

What is bile?

A
  • Stored in gallbladder
  • Alkaline solution – bile salts, phospholipids (aid digestion), bile pigments, cholesterol, neutral fats, electrolytes
31
Q

What are bile salts?

A
  • Cholesterol
    o Emulsify fat
    o Facilitate fat and cholesterol absorption
  • Key bile is bilirubin – waste product of heme
32
Q

What does the gallbladder do?

A
  • Stores bile
  • Releases bile via cystic duct
  • Gallstone – crystalized cholesterol
32
Q

How does bile leave the liver?

A
  • R/L hepatic ducts  common hepatic duct
  • Common hepatic duct  cystic duct  common bile duct
  • Common bile + main pancreatic duct  duodenum at hepatopancreatic ampulla
33
Q

What is the exocrine function of the pancreas?

A
  • Secrete pancreatic juice via main pancreatic duct  duodenum
34
Q

What makes up pancreatic juice?

A
  • Water solution = enzymes + electrolytes (neutralizes acidity in stomach)
  • Pancreatic proteases are active in duodenum
  • Pan enzymes are secreted actively but need bile
    o Pancreatic amylase (carbs)
    o Lipase
    o Nuclease
35
Q

What are the three unique features of the large intestine?

A
  • Teniae coli – 3 bands of longitudinal smooth muscle
  • Haustra – pocket sacs cased by teniae coli
  • Epiploic appendages – fat filled pouches
36
Q

What are the five subdivisions of the large intestine?

A
  • Cecum
    o Appendix – plays role in immunity and gut bacteria
  • Appendix
  • Colon
  • Rectum
  • Anal canal
37
Q

How does bacteria work in the large intestine?

A
  • Gets in from small intestine –> cecum or anus
  • Synthesize B and K vitamins
  • Ferment indigestible carbs –>flatus (dimethyl sulfide)
38
Q

How are carbs digested?

A
  • Small intestine
    o Pancreatic amylase + brush border enzymes
39
Q

How are proteins digested?

A
  • Stomach – pepsin
  • Small intestine
    o Pancreatic proteases
    o Brush border enzymes
40
Q

How are fats digested?

A
  • Mouth – lingual lipase
  • Stomach – gastric lipase
  • Small intestine
    o Emulsifications via bile salts
    o Pancreatic lipase
41
Q

How are nucleic acids digested?

A
  • Small intestine
    o Pancreatic ribonuclease
    o Brush border enzymes