Digestion/Absorption Disorders Flashcards
Zollinger-Ellison Syndrome
Gastrin secreting tumor
Ulcers in later duodenum (2nd/3rd part)
Celiac Sprue
Inappropriate immune response to gluten.
Steatorrhea + Bloating
Overproduction of IgA and IgG
Deficiencies in Vit. K, Vit. D, B12
Lactose Intolerance
Watery Diarrhea
Increased Breath H+ Test
Decreased Serum Glucose
Enteropeptidase Deficiency
Cannot digest proteins in duodenum
No activation of Trypsin
Hypoproteinemia
Appears like Kwashiorkor
Appears like Kwashiorkor
Enteropeptidase Deficiency
Glucose/Galactose Malabsorption
Mutation in SGLT1
Increased Breath H+ Test
Decreased blood glucose and galactose
Treatment: Fructose only diet
Fructose Malabsorption
Mutation in GLUT5
Diarrhea, decreased serum Fructose
Mutation in SGLT1
Glucose/Galactose Malabsorption
Hartnup
Defect in neutral AA transporters
In developed countries, high protein diets allow neutral AA’s to be absorbed as di- and ti-peptides
Cystinuria
Defect in CATIONIC amino acid transporter
Lys, Arg, Orn, Cys
Accumulation of Cysteine kidney stones
Defect in CATIONIC amino acid transporter
Lys, Arg, Orn, Cys
Cystinuria
Hereditary Hemochromatosis
Mutation in HFE-gene Decreased Hepcidin Expression More transport through Ferroportin Transferrin (LOW) Transferrin Saturation (High) Ferritin (High) - storage
Normal Fecal Osmolality
Basic/Neutral pH
Secretory Diarrhea
HIGH Fecal Osmolality
Acidic pH
Osmotic Diarrhea
Improves with fasting
Osmotic Diarrhea
