Digestion + absorption Flashcards
protein digestion
trypsin = proteins to polypeptides
chymotrypsin = proteins to polypeptides
carboxylopeptidase = peptides to amino acids
fat digestion
lipase = fat to fatty acids and monoglycerides
cholesterol esterase = hydrolyses cholesterol esters
phospholipase = separate fatty acids and phospholipids
carb digestion
amylase = glycogen to disaccarides AND hydrolyses starch
Vitamin A
retina, eyesight
vitamin D
calcium metabolism
vitamin E
liver, protection from toxins
vitamin K
activate clotting factors
causes of malsigestion
exocrine pancreatic insufficiency
enzyme deficiency
bile acid deficiency
loss of brush border enzymes
causes of EPI
pancreatic acinar atrophy - selective destruction of acinar cells
chronic pancreas inflammation - pancreatitis
clinical signs of EPI
weight loss
increased feacal vol
abnormal feaces
flatulence
coprophagia
enterocytes function
absorptive cells in SI
absorb Na, glucose and amino acids across brush border
crypt base SI function
stem cells on SI that allow Na to leak into intestinal lumen
four basic mechanisms of diarrhea
altered epithelial cell transport
altered structure or permeability of mucosa
osmotic effects
altered motility
two types of altered motility in SI
hypermotility - faster absorption
hypomotility - slow absorption = bacteria growth