Diffuse Lung Diseases

Question 1

What are diffuse lung diseases ?

Answer 1

Group of diseases ccc by bilateral patchy chronic inflammation of

Parencyhma (Capillary endothelium. Alveolar epithelium and BM)
Insterstitium (perivascular and perilymphatics)

Question 2

Mc cause of diffuse lung disease

Answer 2

Interstitial pulmonary fibrosis

Question 3

What are the risk factors of diffuse lung diseases?

Answer 3

Males
60s
Smoker
Positive family
Viral

Question 4

What is the etiology of DLD?

Answer 4

Activation of fibroblast leading to fibrosis

Question 5

What is the CP triad of DLD?

Answer 5

Gradual Dyspnea >6m
Chronic dry cough
Clubbing

Question 6

What are the complications?

Answer 6

-Pneumonia Bronchiactsis pneumothorax
- bronchogenic carcinoma

-Corpulmonale and pulmonary embolism

Question 7

What is the treatment of DLD?

Answer 7

Patient education (smoking cessation, vaccination)

Lung transplantation

Drugs:
Nintendenab (TKI)
Pirfindone (antifibrotics)
Acetyl cysteine (antifirbotic)
Prednisone (CS)600mg X3d
Azathioprine (CS)

Question 8

Outline the investigations of DLD?

Answer 8

I -> symmetrical chest/ bilateral limited movement

Per-> Dullness

Palp-> TVF equally increased on both sides and centralized trachea

Ausculation: harsh vesicular with decreased airway entry bilaterally and fine crepitation

Question 9

What are the investigations and results of DLD

Answer 9

Spirometry:
• FEV1 less
• FVC less
• TLC less
• FEV1/FVC more than 0.7

HRCT to differentiate between obstructive and restrictive lung disease

Functional state: 6 minute walking test

Echo: corpulmonale and pulmonary HTN

Biopsy: honeycombing
BAL: lymphocytosis more than 30% exclude
DLco: impaired