Diffuse Lung Disease Flashcards
Which type of interstitial fibrosis can be steroid responsive?
Non-specific interstitial pneumonia
What makes up the interstitium histologically?
Alveolar lining cells (Type I and II epithelial cells)
Epithelial basement membrane
Endothelial basement membrane and cell
What are some diffuse diseases that effect the interstitium?
Fibrosis
Interstitial pneumonia
What might a patient with appear diffuse lung disease present on examination?
Stiff lungs
Cough
Dyspnoeic
Increased use of accessory muscles
Tachypnoea
What is NSIP
What does ground glass opacity refer to?
Found on HRCT, often indicate alveolar involving infections
What are some common drugs that cause interstitial lung disease?
Methotrexate
Amiodarone
Bleomycin
Busulphan
Cyclophosphomide
Nitrofurantoin
Generally, what patterns of opacity do you get in alveolar vs interstitial pathology?
Alveolar - fluffy
Interstitial - Linear
What does a reduced diffusion capacity on lung function tests indicate?
Interstitial lung pathology
What are some diseases that effect the conducting airways?
COPD
Asthma
What are some diffuse diseases that effect the pulmonary vascular?
Pulmonary hypertension
PE
Vasculitis
What symptom is characteristic of bronchiectasis?
Large volume of sputum
What are the types of patterns of interstitial pathology on CXR?
Linear
Nodule
Reticular
Reticulonodular
What are some diseases that effect the alveoli?
APO
Pneumonia
What are the radiological findings of a patient with usual interstitial pneumonia?
Basal and peripheral fibrosis
Honeycombing
