Differential diagnostics

Question 1

Conditions mimicing HCPH but w/o inadequate CSF absorptuion - PSeudohydrochephalus

Answer 1

*hcph ex vacu - loss of cerebral tissue
* developmental anomalies

Question 2

reasons for hydrocephalus ex vacuo

Answer 2

• normal aging
• Alzheimers disease
• Creutzfeld Jacob disease
• TBI

Question 3

Diff from external hcph

Answer 3

• benign subdural collections of infancy
• symptomatic chronic extra-axial fluid collections p939

Question 4

What is a cortical vein sign?

Answer 4

MRI or CT may demonstrate cortical veins extending from the surface of the brain to the inner tabulae of the skull bone.
This can only be seen if the collection is subarachnoidal. If it is subdural it will somehow push the veins toward the brain so they get compressed.
Jag fattar inte detta resonemang men men. Iallafall typiskt för tillståndet.

Question 5

what signs are not expected in NPH?

Answer 5

• papilledema
• seizures preoperatively
• headaches
• spasticity
• hyperreflexia
• lateralizing findings

Question 6

The two most common differential diagnostics to NPH

Answer 6

• Alzheimer disease
• Parkinsons disease

Question 7

Headline conditions similar presentation to NPH

Answer 7

• neurodegenerative disorders
• Vascular dementia
• Other hydrocephalic disorders
• Infectious disease
• Urological disorder
• Mischelaneous

Question 8

What neurodegenerative diseases might present as NPH?

Answer 8

• Alzheimer
• Parkinson
• Lewy body demens
• Huntingtons
• Frontotemporal dementia
• Corticobasal degeneration
• progressive supranuclear palsy
• amyotrophic lateral sclerosis
• multisystem atrophy
• spongiform encephalopathy

Question 9

what vascular dementias might present as NPH?

Answer 9

• cerbrovascular disease
• multi-infarct dementia
• Binswangers disease
• CADASIL
• vertebrobasilar insufficiency