Differential diagnosis ( kumar's review and Neviel Book) Flashcards
Solitary pigmented
lesion
DDx
Kumar lecture
- Amalgam tattoo
- Melanocytic nevus
- Melanotic macule
- Post‐inflammatory melanosis
- Melanoma
Nodule on gingiva
(3P’s)
DDx
Kumar lecture
- Pyogenic granuloma
- Peripheral ossifying fibroma
- Peripheral giant cell granuloma
- Fibroma
- Parulis (not interproximal though)
- Gingival cyst (not interproximal though)
White Patch‐
Leukoplakia
(Oral Potentially
Malignant Disorder)
• Epithelial hyperplasia
• Epithelial hyperkeratosis
• Epithelial dysplasia
• Carcinoma‐in‐situ
• Squamous cell carcinoma
*Other white patches with an explanation (NOT OPMD)
• Hyperplastic candidiasis
• Frictional keratosis
• Oral hairy leukoplakia
Solitary non‐healing
ulcer
DDx
Kumar lecture
- Squamous cell carcinoma
- Traumatic ulcer
- Fungal ulcer
- Tuberculosis ulcer
- Major aphthous ulcer (immune related)
- Syphilitic chancre
Multilocular lesion
DDx
Kumar lecture
MACHO
- M‐myxoma
- A‐ameloblastoma
- C‐central giant cell granuloma
- H‐hemangioma
- O‐odontogenic keratocyst
- Cherubism (bilaterally)
- Intra‐osseous mucoepidermoid carcinoma
Radiolucency at
apex of decayed
tooth
DDx
Kumar lecture
- Periapical/radicular cyst
- Periapical/radicular granuloma
- Periapical/radicular abscess
- Periapical/radicular scar
Well‐defined
radiolucency
around crown
impacted molar
post. md
DDx
Kumar lecture
- D‐Dentigerous cyst
- O‐Odontogenic keratocyst
- A‐Ameloblastoma
Non‐ulcerated soft
tissue swelling in
tongue (or
submucosal)
DDx
Kumar lecture
- Granular cell tumor
- Neurofibroma
- Neuroma
- Schwannoma
- Deep hemangioma
- Fibroma
- Deep lipoma
- Include salivary gland neoplasm
Petechiae on palate
- • Scarlet fever
- • Infectious mononucleosis
- • Trauma
• NOT nicotine stomatitis
Swollen tonsils
DDx
Kumar lecture
- Infectious mononucleosis
- Streptococcal tonsillitis
Palatal lesions
DDx
Kumar lecture
- Necrotizing sialometaplasia
- Nicotine stomatitis
- Papillary hyperplasia of the palate
- Denture stomatitis
- Gumma
- Median palatine cyst
- Salivary gland tumor
- Cocaine abuse
- Leprosy
Swelling of palate
midline
DDx
Kumar Lecture
Torus
Median Palatal Cyst
Swelling of palate
DDx
Kumar Lecture
(not midline)
- Pleomorphic adenoma
- Adenoid cystic carcinoma (pain)
- Mucoepidermoid carcinoma (blue hue)
- Odontogenic tumor
- Abscess
Skull film
DDx
Kumar Lecture
- • Paget
- • Sickle cell anemia
- • Thalassemia
- • Multiple myeloma
- • Hand Schuller
Perioral crusts
DDx
Kumar Lecture
- Impetigo (amber/cornflakes stuck on skin)
- Recurrent herpes
Crops of coalescing
ulcers
- Recurrent herpes on palate/gingiva ( infectious category)
- Herpetiform aphthous (inflmatory category)
Conical teeth
DDx
Kumar Lecture
- Ellis van Creveld (chondroectodermal dysplasia)
- Hypohidrotic ectodermal dysplasia
Low Risk HPV
Tumors
- Verruca vulgaris (common wart)
- Squamous papilloma
- Condyloma acuminatum
High risk HPV
DDx
Kumar Lecture
- Oropharyngeal squamous cell carcinoma
- Cervical cancer
Angular cheilitis
cause
- Candida
- Iron deficiency
- B12 deficiency
- Pernicious anemia
- Folic acid deficiency
Multiple melanotic
macules
DDx
Kumar
- Peutz Jeghers
- Addison disease
Benign fibroosseous
lesions
DDx
Kumar
- Central cemento‐ossifying fibroma (neoplasm)
- Periapical cemento‐osseous dysplasia
- Florid cemento‐osseous dysplasia
- Focal cemento‐osseous dysplasia
- Fibrous dysplasia
- All have same histopathology therefore need an xray
Sun exposure
DDx
Kumar
- Basal cell carcinoma
- Actinic cheilitis
Recessive
DDx
Kumar
- Papillon Lefevre (autosomal)
- Chondroectodermal dysplasia (autosomal)
- Hypophosphatasia (autosomal)
- Hypohidrotic ectodermal dysplasia (X‐linked)
Café‐au‐lait
pigmentation
ddx
Kumar
- Polyostotic fibrous dysplasia
- Neurofibromatosis of von Recklinghausen
Looks like
periodontitis
DDx
Kumar
- Langerhans cell disease
- Papillon Lefevre
Teeth “floating in
air” in childrenalveolar
bone loss
DDx
- Juvenile periodontitis
- Langerhans cell disease
- Papillon Lefevre
- Cyclic neutropenia/Agranulocytosis
- Burkitt’s lymphoma
Face/Angle swelling
List of dx
- Sjogren (parotid)
- Pleomorphic adenoma (parotid)
- Warthin tumor (parotid)
- Ameloblastoma (mandible)
- Cherubism (bilateral)
- Fibrous dysplasia (unilateral)
- Mumps (bilateral usu.)
- HIV (lymphoepithelial cysts)
- Bulimia
- Alcoholism
These are Intra osseous pathologies, what are the their Extra Osseous counterpart ?
• Lateral periodontal cyst
• Dentigerous cyst
• Central giant cell granuloma
- Lateral periodontal cyst‐Gingival cyst
- Dentigerous cyst‐Eruption cyst
- Central giant cell granuloma‐Peripheral giant cell granuloma
Tumors that sound
benign but are
malignant
- Melanoma
- Lymphoma
Same under
microscope
ddx
• Congenital epulis
• Granular cell tumor
Desquamative
gingivitis
ddx
• Erosive lichen planus
• Mucous membrane pemphigoid
• Pemphigus vulgaris
• Erythema multiforme
What are the Differential for the following:
• Glossitis
• Angular cheilitis
• Atrophy of papillae on tongue
• Pallor
1) Iron deficiency anemia
2) Pernicious anemia
3) Folic acid and B12 deficiency
4) Celiac sprue
What are the Differential for
gingival bleeding?
• Aplastic anemia
• Polycythemia
• Leukemia
• Thrombocytopenic purpura
• Hemophilia
Drugs that cause
gingival
enlargement
(gingival hyperplasia)
• Cyclosporine
• Phenytoin
• Nifedipine
Gingival
enlargement
• Leukemia
• Drug induced
Associations
With what the following are assoiciated?
• Heart shape
• Scalloping
• Ghost teeth
• Ghost cells
• Heart shape‐Nasopalatine canal cyst
• Scalloping‐traumatic bone cyst
• Ghost teeth‐regional odontodysplasia
• Ghost cells‐calcifying odontogenic cyst
Associations
With what the following are assoiciated?
• X looks like a “t”
• Snow capped
• Pebbly
• Pearly doughnut with ulcer and telangiectactic blood vessels•
• X looks like a “t”‐Turner
• Snow capped‐amelogenesis imperfecta
• Pebbly‐Verrucous carcinoma, lymphangioma
• Pearly doughnut with ulcer and telangiectactic blood vessels‐basal cell carcinoma
Associations
With what the following are assoiciated?
• Swiss cheese
• Tennis raquet, step ladder
• Bag of marbles
- Swiss cheese‐adenoid cystic carcinoma
- Tennis raquet, step ladder‐myxoma
- Bag of marbles‐compound odontoma
Associations
With what the following are assoiciated?
• Hair on end
• Mosaic jigsaw
• Cobblestone
• Sunray spiculated pattern
- Hair on end‐thalassemia and sickle cell anemia
- Mosaic jigsaw‐Paget histology
- Cobblestone‐Crohn, papillary hyperplasia
- Sunray spiculated pattern‐Osteosarcoma
Malignancy
Association
With what the following are assoiciated?
• Gardner syndrome
• Gorlin
• Multiple endocrine neoplasia
• Neurofibromatosis of von Recklinghausen
• Gardner syndrome‐Malignant GI polyps
- Gorlin – Basal cell carcinoma
- Multiple endocrine neoplasia –Medullary thyroid carcinoma
- Neurofibromatosis of von Recklinghausen‐Malignant transformation of neurofibromas
What we can find in the xray of the following?
• Amelogenesis imperfecta‐
• Dentinogenesis imperfecta‐
• Dentin dysplasia type 1
• Dentin dysplasia type 2
• Amelogenesis imperfecta‐ “crown preps” and taurodontism
• Dentinogenesis imperfecta‐bulbous crown no root canal, shell teeth
• Dentin dysplasia type 1‐ “rootless teeth”
• Dentin dysplasia type 2‐ “thistle tube”
Polyps‐benign or
malignant?
• Gardner
• Peutz Jegher‐
- Gardner (malignant)
- Peutz Jegher (benign)
What syndrom has Opalescent
• Teeth =
• Mucosa=
- OpalescentTeeth=Dentinogenesis imperfecta and osteogenesis imperfecta
- Opalescent Mucosa=Leukoedema
What are other names for the followings?
**• Ellis van Creveld
• Gorlin
• Treacher Collin
**
- Ellis van Creveld‐Chondroectodermal dysplasia
- Gorlin‐Nevoid basal cell carcinoma
• Treacher Collin‐Mandibulofacial dysostosis
\
What are other names for the followings?
• Osler Rendu Parkes Weber
• Canon
• Pindborg
- Osler Rendu Parkes Weber – Hereditary hemorrhagic telangiectasia
- Canon‐White sponge nevus
- Pindborg tumor‐Calcifying epithelial odontogenic tumor
The following cells are found when:
• Neutrophil –
• B lymphocyte –
• Plasma cell –
- *•** Neutrophil – acute inflammation
- *• B lymphocyte** – makes plasma cells (chronic)
- *• Plasma cell** – makes antibodies (chronic)
The following cells are found when:
• Macrophage –
• Eosinophil and Langerhan cell –
• Eosinophil‐
• Mast cell –
• Macrophage – phagocytosis (both acute and chronic)
• Eosinophil and Langerhans cell – Langerhans cell disease
• Eosinophil ‐ allergy
• Mast cell – allergy
What are the synonymous names of the following
• Stafne bone cyst
• Traumatic bone cyst
• White sponge nevus
• Stafne bone cyst – Static bone cyst=saliv.gland
• Traumatic bone cyst –Simple bone cyst=empty
• White sponge nevus – Canon disease
What are the synonymous names of the following:
• Gorlin syndrome
• Benign migratory glossitis
• Wart
• Canker sore
\
• Gorlin syndrome – Nevoid basal cell carcinoma syndrome
• Benign migratory glossitis – Geographic tongue –Erythema migrans
• Wart – Verruca vulgaris
• Canker sore – Minor aphthous ulcer
What are the synonymous names of the following:
- Dens in dente
- Freckle
- Birth mark
- Mole
• Dens in dente – Dens invaginatus ‐Tooth within a tooth
- Freckle‐Ephelis‐ Melanotic macule (NOT MACULE ALONE)
- Birth mark‐Nevus‐Melanocytic nevus
- Mole‐Melanocytic nevus
What are Descriptive associations of the following:
• Explosive onset
• Gets larger and smaller
• Attached mucosa
- Explosive onset – Erythema multiforme
- Gets larger and smaller – mucocele
- Attached mucosa – Recurrent herpes
What are Descriptive associations of the following:
- Movable mucosa
- Urticaria
- Angioedema
• Movable mucosa – Aphthous ulcers
• Urticaria – superficial
• Angioedema – deep
What are Descriptive associations of the following:
- Female/max/canine?
- Compound odontoma
- Complex odontoma
• Female/max/canine?‐Adenomatoid odontogenic tumor
• Compound odontoma‐anterior max
• Complex odontoma‐posterior md
What are Descriptive associations of the following:
- Yellow with superficial blood vessels
- Most common malignant soft tissue tumor of head and neck children
- Cluster of coalescing ulcers unilateral
• Yellow with superficial blood vessels‐lipoma
• Most common malignant soft tissue tumor of head and neck childrenrhabdomyosarcoma
• Cluster of coalescing ulcers unilateral‐recurrent intraoral herpes
What are the following classic pics related to?
• Draining sinus at angle
• Loss of primary teeth
• Hole in palate
• Draining sinus at angle –actinomycosis
- Loss of primary teeth‐ hypophosphatasia
- Hole in palate‐Gumma
Common Errors
- Dysplasia‐microscopic term
- Leukoplakia‐clinical term
- Pericoronitis‐clinical term not radiographic
- Varicella zoster virus‐chicken pox/herpes zoster
- Oral hairy leukoplakia CORRUGATED‐ EBV
- Mucocele (granulation tissue lined) vs mucous cyst (epithelial lined)
White Lesions: Can Be Scraped Off
DDx
Bold and underlines most likely
Bold second most likely
italic least likely
Neivel book
- White coated tongue May be scraped off slightly, with dif!culty
- Pseudomembranous candidiasis “Milk curd” or “cottage cheese” appearance; may leave red base when rubbed off
- Morsicatio Surface may appear to be peeling off
- Toothpaste or mouthwash reaction Filmy whiteness; leaves normal appearing mucosa when rubbed off
- Thermal burn Example: pizza burn
- Sloughing traumatic lesion Example: cotton roll “burn”
- Chemical burn Example: aspirin burn secondary to direct application for toothache
- Secondary syphilis Mucous patch; may be only partially scraped off
- Diphtheria Gray-white pseudomembrane of oropharynx
White Lesions: Cannot Be Scraped Off
DDx
(long list just know what’s relevant to us)
Bold and underlines most likely
Bold second most likely
italic least likely
- Linea alba Buccal mucosa along occlusal plane
- Leukoedema Primarily in blacks; milky white alteration of buccal mucosa
bilaterally; disappears when stretched - Leukoplakia May show benign hyperkeratosis, epithelial dysplasia, or invasive carcinoma
- Tobacco pouch keratosis Usually in mandibular vestibule; associated with use of snuff or chewing tobacco
- White coated tongue Diffuse involvement of dorsal tongue
- Lichen planus Wickham’s striae; typically bilateral on buccal mucosa
-
Morsicatio Most common on anterior buccal mucosa, labial mucosa, and
lateral border of tongue; exhibits ragged surface - Actinic cheilosis Pale, gray-white, scaly alteration of lower lip; usually in older men with history of chronic sun exposure; precancerous
- Nicotine stomatitis Usually associated with pipe smoking; occurs on hard palate
- Hairy leukoplakia Usually lateral border of tongue; rough surface with vertical !ssures; usually associated with HIV infection
- Hyperplastic candidiasis Most commonly affects anterior buccal mucosa
- Lupus erythematosus Most common on buccal mucosa; may mimic lichen planus or leukoplakia; associated skin lesions usually present
- Skin graft History of previous surgery
- Submucous fibrosis More common in South Asia; associated with betel quid chewing
- White sponge nevus Hereditary; onset in childhood; generalized lesions, especially buccal mucosa
- Hereditary benign intraepithelial dyskeratosis Hereditary; onset in childhood; generalized lesions, especially buccal mucosa; ocular involvement possible
- Pachyonychia congenita Hereditary; onset in childhood; most common on dorsal tongue and areas of trauma; nail, palmar, and plantar changes also present
- Dyskeratosis congenita Hereditary; onset in childhood; dystrophic nail changes
- Uremic stomatitis Renal failur
Red Lesions
Bold and underlines most likely
Bold second most likely
italic least likely
- Pharyngitis Examples: strep throat, viral pharyngitis
- Traumatic erythema Caused by local irritation
- Denture stomatitis Denture-bearing palatal mucosa
- Erythematous candidiasis Example: central papillary atrophy (median rhomboid glossitis)
- Erythema migrans Geographic tongue (cases with absence of white borders); continually changing pattern; rarely involves other mucosal sites
- Angular cheilitis Erythema and cracking at labial commissures
- Thermal burns Example: caused by hot liquids
- Erythroplakia Usually shows epithelial dysplasia or carcinoma
- Anemia Atrophic, red tongue; can be due to pernicious anemia, ironde
deficiency anemia, hypovitaminosis B - Hemangioma Develops in younger patients; may blanch; may show bluish hue
- Lupus erythematosus Usually with associated skin lesions
- Scarlet fever Secondary to B-hemolytic streptococcal infection; strawberry/ raspberry tongue
- Plasma cell gingivitis Allergic reaction usually related to “avoring agents
- Radiation mucositis Patient currently undergoing radiotherapy
White and Red Lesions
DDx
Bold and underlines most likely
Bold second most likely
italic least likely
- Erythema migrans Geographic tongue; continually changing pattern; rarely involves other oral mucosal sites
- Candidiasis White component may be rubbed off
- Lichen planus Atrophic or erosive forms; Wickham’s striae; typically bilateral on buccal mucosa
-
Burns Examples: pizza burn, aspirin burn, other chemical burns; white
component may be rubbed off - Actinic cheilosis Pale, gray-white and red alteration to lower lip; usually in older men with history of chronic sun exposure
- Erythroleukoplakia Usually shows epithelial dysplasia or carcinoma
- Cinnamon reaction Related to cinnamon “avored gum; typically on buccal mucosa and lateral tongue
- Nicotine stomatitis Usually associated with pipe smoking; occurs on hard palate
- Lupus erythematosus Most common on buccal mucosa; may mimic lichen planus or leukoplakia; associated skin lesions usually present
- Scarlet fever Secondary to B-hemolytic streptococcal infection; strawberry/ raspberry tongue
- Verruciform xanthoma Most common on gingiva and hard palate; surface may be papillary
Yellow Lesions
ddx
- Fordyce granules Sebaceous glands; usually multiple submucosal papules on buccal mucosa or upper lip vermilion
- Super facial abscess Example: parulis from nonvital tooth
- Accessory lymphoid aggregate Most common in oropharynx and “oor of mouth; may exhibit orange hue
- Lymphoepithelial cyst Most common on lingual and palatine tonsils, and “oor of mouth;
- may be yellow-white
- Lipoma Most common on buccal mucosa; soft to palpation 488
- Jaundice Generalized discoloration, especially involving soft palate and “ floor of mouth; sclera usually affected also
- Verruciform xanthoma Most common on gingiva and hard palate; surface may be rough or papillary
- Pyostomatitis vegetans “Snail-track” pustules; associated with in”ammatory bowel disease
Blue and/or Purple Lesions
- Varicosities Especially after 45 years of age; most common on ventral tongue and lips
- Submucosal hemorrhage Petechial, Ecchymotic, and Telangiectatic Lesions
- Amalgam tattoo Most common on gingiva; blue-gray; radiopaque amalgam particles sometimes discovered on radiographs
- Mucocele Especially on lower labial mucosa; typically pale blue; cyclic swelling and rupturing often exhibited
- Eruption cyst Overlying an erupting tooth
- Salivary duct cyst Usually pale blue
- Hemangioma Usually red-purple; may blanch under pressure; onset in younger patients
- Ranula Pale blue, “uctuant swelling of lateral “oor of mouth
- Kaposi sarcoma Especially in AIDS patients; usually purple; most common on palate and maxillary gingiva
- Nasopalatine duct cyst Midline of anterior palate
- Salivary gland tumors Especially mucoepidermoid carcinoma and pleomorphic adenoma; usually pale blue; most common on posterior lateral palate
- Gingival cyst of the adult Most common in mandibular bicuspid-cuspid region
- Blue nevus Most common on hard palate
Soft Tissue Masses (Lumps and Bumps): Midline Neck Lesions
DDX
- Thyroid gland enlargement Examples: goiter, thyroid tumor
- Thyroglossal duct cyst May move up and down with tongue motion
- Dermoid cyst Soft and fluctuant
- Plunging ranula Soft and compressible
Brown, Gray, and/or Black Lesions
- Racial pigmentation Most common on attached gingiva in darker complexioned patients
- Amalgam tattoo Most common on gingiva; usually slate-gray to black; opaque amalgam particles may be found on radiographs
- Black/brown hairy tongue Discoloration and elongation of filiform papillae
- Melanotic macule Brown; most common on lower lip
- Smoker’s melanosis Most common on anterior facial gingiva
- Non-amalgam tattoo Example: graphite from pencil
- Melanocytic nevus Most common on hard palate; can beflat or raised
- Melanoma Most common on hard palate and maxillary gingiva; may show mixture of deep blue, brown, black, and other colors
- Oral melanoacanthoma Rapidly enlarging pigmented lesion; usually occurs in blacks
- Drug ingestion Examples: chloroquine, chlorpromazine, minocycline; especially on hard palate
- Peutz-Jeghers syndrome Freckle-like lesions of vermilion and perioral skin; intestinal polyps; hereditary
- Addison disease Chronic adrenal insuf!ciency; associated with bronzing of skin
- Neuro!bromatosis type I Café au lait pigmentation; cutaneous neuro!bromas
- McCune-Albright syndrome Café au lait pigmentation; polyostotic !brous dysplasia; endocrine disorders
- Heavy metal poisoning Typically along marginal gingiva (e.g., lead, bismuth, silver)
- Melanotic neuroectodermal tumor of infancy:Anterior maxilla; destroys underlying bone
Papillary Growths: Focal or Diffuse
- Hairy tongue Usually brown or black discoloration; hyperkeratotic elongation of !liform papillae on posterior dorsal tongue
- Papilloma Can be white or pink; most common on soft palate and tongue; usually pedunculated
- Inflammatory papillary hyperplasia Usually involves midportion of hard palate beneath denture
-
Leukoplakia (some variants) Examples: proliferative verrucous leukoplakia, granular or nodular
leukoplakia - Squamous cell carcinoma Examples with papillary surface changes
- Giant cell fibroma Usually in children and young adults; most common on gingiva
- Verruca vulgaris Common wart; especially in younger patients; most common on labial mucosa
- Hairy leukoplakia Usually lateral border of tongue; rough surface with vertical fissures; usually associated with HIV infection
- Verruciform xanthoma Most common on gingiva and hard palate
- Verrucous carcinoma Especially in older patients with long history of snuff or chewing tobacco use; especially in mandibular vestibule and buccal mucosa; may be white or red
- Condyloma acuminatum Venereal wart; broad-based lesions with blunted projections; frequently multiple
- Multifocal epithelial hyperplasia Usually multiple, “at-topped papular lesions; usually in children; most common in Native Americans and Inuit; color may vary from normal to white
- Darier’s disease Most commonly appears as pebbly appearance of hard palate; associated crusty, greasy skin lesions; hereditary
- Acanthosis nigricans (malignant type) Most commonly appears as generalized pebbly alteration of upper lip; pigmented, pebbly skin changes
Petechial, Ecchymotic, and Telangiectatic Lesions
DDx
Bold and underlines most likely
Bold second most likely
italic least likely
- Nonspecific trauma History of injury to lesional site
- Upper respiratory infections Soft palate petechiae
- Infectious mononucleosis Soft palate petechiae; tonsillitis and/or pharyngitis may be present
- Idiopathic thrombocytopenic purpura Areas of trauma; gingival bleeding possibly present
- Trauma from fellatio Posterior palatal petechiae or ecchymosis
- Hemophilia Hereditary; childhood onset; gingival bleeding may be present
- Leukemia Caused by secondary thrombocytopenia; gingival bleeding may be present
- Hereditary hemorrhagic telangiectasia Multiple, pinhead-sized telangiectasias; possible history of nosebleeds or gastrointestinal bleeding
- CREST syndrome Multiple, pinhead-sized telangiectasias; Calcinosis cutis, Raynaud’s phenomenon, Esophageal motility defect, Sclerodactyly, Telangiectasias
Generalized Gingival Enlargement
- Hyperplastic gingivitis Examples: associated with puberty, pregnancy, diabetes
- Drug-related gingival hyperplasia Examples: phenytoin, calcium-channel blockers, cyclosporine; may be fibrotic
- Gingival fibromatosis May be hereditary; onset in childhood
- Leukemic infiltrate Usually boggy and hemorrhagic
- Wegener granulomatosis “Strawberry” gingivitis; may have palatal ulceration and destruction; lung and kidney involvement
- Scurvy Vitamin C deficiency
Vesiculoerosive and Ulcerative Lesions: Acute (Short Duration and Sudden Onset)
DDx
- Traumatic ulcer Mild-to-moderate pain; history of local trauma
- Aphthous stomatitis Extremely painful; may be single or multiple; nonkeratinized movable mucosa; often recurs
- Recurrent herpes labialis Vermilion and labial skin; begins as multiple vesicles; often recurs
- Primary herpetic gingivostomatitis Fever and malaise; children and young adults; multiple vesicles; gingiva consistently affect
-
Necrotizing ulcerative gingivitis (NUG) Painful destruction of gingival papillae; fetid odor; mostly in teenagers and young adults
Mucosal burns Chemical or thermal - Recurrent intraoral herpes simplex Gingiva or hard palate (except in immunocompromised); focal cluster of vesicles and shallow ulcers
- Allergic reactions Example: Caused by topical medications or dental materials;
erythema and vesicles -
Erythema multiforme / Stevens-Johnson syndrome
Predominantly in children and young adults; multiple blisters and
ulcers; often crusting, hemorrhagic lip lesions; may have
associated “target” skin lesions or involvement of ocular and
genital mucosa - Herpangina Especially in children; multiple small ulcers on soft palate and tonsillar pillars
- Varicella (chickenpox) Associated with skin eruption; few oral vesicles and ulcers; usually in children
- Herpes zoster Unilateral involvement along nerve distribution; usually middle-aged and older adults; painful vesicles and ulcers
- Hand-foot-and-mouth disease Especially in children; multiple vesicles and ulcers; associated vesicles on hands and feet
- Necrotizing sialometaplasia Usually posterior lateral hard palate; prior swelling may be present; deep crater-like ulcer; may be only minimal pain
- Anesthetic necrosis Usually at site of palatal injection
- Primary syphilis Chancre at site of inoculation; usually painless with lean ulcer bed
- Behçet syndrome Aphthous-like ulcers; genital ulcers and ocular in”ammation
Vesiculoerosive and Ulcerative Lesions: Chronic (Long Duration)
- Erosive lichen planus Associated with white striae; usually in middle-aged and older adults; most common on buccal mucosa and gingiva
- (“desquamative gingivitis”)
- Traumatic granuloma Solitary, non-healing ulcer
- Squamous cell carcinoma Usually in middle-aged and older adults; usually indurated and may have rolled border; may be painless
- Mucous membrane pemphigoid Most common in middle-aged and older women; most commonly presents as a “desquamative gingivitis”; may involve ocular and genital mucosa
- Lupus erythematosus May have associated red and white change; usually with skin involvement
- Pemphigus vulgaris Usually in middle-aged and older patients; multiple oral blisters and ulcers usually precede skin lesions
- Deep fungal infections Examples: histoplasmosis, blastomycosis; may be painless
- Tuberculosis Associated mass may be present; may be painless
- Sarcoidosis May be associated with erythematous macules or plaques; may be painless
- Epidermolysis bullosa Hereditary (except epidermolysis bullosa acquisita); onset in infancy and childhood; multiple skin and oral blisters or ulcers in areas of trauma; may result in extensive scarring
- Pyostomatitis vegetans Yellowish “snail-track” pustules; associated with in”ammatory bowel disease
- Wegener granulomatosis Usually palatal ulceration and destruction; associated lung and kidney involvement may be present; may show “strawberry gingivitis”
- Extranodal NK/T-cell lymphoma, nasal-type (midline lethal granuloma) Palatal lymphoma with ulceration and destruction of underlying bone; may be painless
- Noma Gangrenous necrosis secondary to necrotizing ulcerative gingivitis; usually in malnourished children or immunocompromised
- individuals
- Tertiary syphilis Gumma; associated mass may be present; may be painless; may perforate palate
Soft Tissue Masses (Lumps and Bumps): Hard or Soft Palate
DDx
- Palatal abscess Associated with nonvital tooth
- Leaf-like denture fibroma Pedunculated hyperplastic growth beneath ill-fitting denture
- Salivary gland tumors Especially pleomorphic adenoma, mucoepidermoid carcinoma,
- adenoid cystic carcinoma, polymorphous low-gradeadenocarcinoma; may have bluish hue
- Nasopalatine duct cyst Fluctuant swelling of anterior midline palate
- Lymphoma Often boggy and edematous; may have bluish hue; may be
bilateral - Kaposi sarcoma Usually purple; may be multiple; usually associated with AIDS
- Other mesenchymal tumors Examples: fibroma, hemangioma, neurofibroma
- Squamous cell carcinoma Tumor with rough, granular, irregular surface; occasionally arises from maxillary sinus
- Mucocele/salivary duct cyst Usually has bluish hue
- Melanocytic nevus/ melanoma Usually pigmented
- Necrotizing sialometaplasia Early stage lesion; often associated with pain or paresthesia
- Adenomatoid hyperplasia of minor salivary glands Asymptomatic, painless mass
Soft Tissue Masses (Lumps and Bumps): Tongue
- Fibroma Usually normal in color; most common on margins of tongue
- Squamous cell carcinoma Tumor with rough, granular, irregular surface; usually lateral or ventral border
- Mucocele Usually anterior ventral surface; usually bluish or clear color
- Pyogenic granuloma Usually red, ulcerated, easily bleeding
- Granular cell tumor Dome-shaped; usually on dorsum of tongue
- Other mesenchymal tumors Examples: lymphangioma, hemangioma, neurofibroma, osseous choristoma
- Salivary gland tumors Especially mucoepidermoid carcinoma and adenoid cystic carcinoma
- Lingual thyroid Usually posterior midline of dorsal surface; usually in women
Soft Tissue Masses (Lumps and Bumps): Floor of Mouth
- Ranula/mucocele Typically a pale blue, “uctuant swelling
- Sialolith Usually hard mass in submandibular duct; may be associated with tender swelling of affected gland; radiopaque mass
- Lymphoepithelial cyst Small, yellow-white submucosal lesion
- Squamous cell carcinoma Tumor with rough, granular, irregular surface
- Epidermoid or dermoid cyst Midline yellow-white submucosal lesion
- Salivary gland tumors Especially mucoepidermoid carcinoma
- Mesenchymal tumors Examples: lipoma, neuro!broma, hemangioma
Soft Tissue Masses (Lumps and Bumps): Gingiva/Alveolar Mucosa
- Parulis Fistula from nonvital tooth
- Epulis fissuratum Ill-fitting denture
- Pyogenic granuloma Usually red, ulcerated, easily bleeding; increased frequency in pregnant women
- Peripheral ossifying fibroma May be red or normal in color; may be ulcerated
- Fibroma Usually normal in color
- Peripheral giant cell granuloma Reddish purple; frequently ulcerated
- Squamous cell carcinoma Tumor with rough, granular, irregular surface
- Metastatic tumors May be painful and destroy bone
- Gingival cyst of the adult Most common in mandibular bicuspid-cuspid region; may be blue
- Traumatic neuroma Edentulous mandible in mental foramen area; often painful to palpation
- Kaposi sarcoma Especially in AIDS patients; usually purple
- Peripheral odontogenic tumors Example: peripheral ameloblastoma
- Congenital epulis Usually in females; especially anterior maxilla 50
- Melanotic neuroectodermal tumor of infancy Anterior maxilla; destroys underlying bone; may be pigmented
- Other mesenchymal tumors Examples: hemangioma, neuro!broma
Soft Tissue Masses (Lumps and Bumps): Buccal Mucosa
- Fibroma Usually normal in color; along occlusal plane
- Lipoma May be yellow; soft to palpation
- Mucocele Typically pale blue; often exhibits cyclic swelling and rupturing
- Hyperplastic lymph node Usually buccinator node; movable submucosal mass
- Other mesenchymal tumors, Examples: hemangioma, neuro!broma Chapter
- Squamous cell carcinoma Tumor with rough, granular, irregular surface
- Salivary gland tumor Pleomorphic adenoma and mucoepidermoid carcinoma most common
Soft Tissue Masses (Lumps and Bumps): Upper Lip
- Fibroma Usually normal in color
- Minor gland sialolith Small, hard submucosal mass: may be tender
- Salivary gland tumor Usually canalicular adenoma (older than age 40) or pleomorphic adenoma (younger than age 40)
- Salivary duct cyst May be bluish
- Other mesenchymal tumors Examples: hemangioma, neuro!broma, schwannoma
- Nasolabial cyst Fluctuant swelling of lateral labial vestibule
Soft Tissue Masses (Lumps and Bumps): Lateral Neck Lesions
Bold and underlines most likely
Bold second most likely
italic least likely
- Reactive lymphadenopathy Secondary to oral and maxillofacial infection; often tender to palpation
- Epidermoid cyst Soft and movable
- Lipoma Soft mass
- Metastatic carcinoma Deposits from oral and pharyngeal carcinomas; usually indurated and painless; may be fixed
- Lymphoma May be unilateral or bilateral; usually painless; Hodgkin and non-Hodgkin types
- Infectious mononucleosis Fatigue; sore throat; tender lymph nodes
- Salivary gland tumors Arising from submandibular gland or tail of parotid gland
- Submandibular sialadenitis Example: secondary to sialolithiasis
- Branchial cleft cyst Soft and “uctuant; most common in young adults
- Granulomatous diseases Examples: tuberculosis, sarcoidosis
- Cat-scratch disease History of exposure to cat
- Cystic hygroma Infants; soft and “uctuant
- Plunging ranula Soft and compressible
- Other mesenchymal tumors Examples: neuro!broma, carotid body tumor
Soft Tissue Masses (Lumps and Bumps): Lower Lip
- Mucocele Typically pale blue; often exhibits cyclic swelling and rupturing; labial mucosa only
- Fibroma Usually normal in color
- Pyogenic granuloma Red, ulcerated, bleeds easily; usually on vermilion border
- Squamous cell carcinoma Tumor with rough, granular, irregular surface; usually on vermilion border
- Other mesenchymal tumors Examples: hemangioma, neuro!broma, lipoma Chapter
- Salivary duct cyst May be bluish; labial mucosa only
- Salivary gland tumor Usually mucoepidermoid carcinoma Chapter
- Keratoacanthoma Volcano-shaped mass with central keratin plug; rapid development; vermilion border only
Unilocular Radiolucencies: Pericoronal Location
- Hyperplastic dental follicle 5 mm in thickness
- Eruption cyst Bluish swelling overlying erupting tooth
- Odontogenic keratocyst —
- Orthokeratinized odontogenic cyst —
- Ameloblastoma Especially unicystic type
- Ameloblastic fibroma Usually in younger patients
- Adenomatoid odontogenic tumor Usually in anterior region of jaws; most often with maxillary canine; usually in teenagers
- Calcifying odontogenic cyst Gorlin cyst
- Carcinoma arising in dentigerous cyst Mostly in older adults
- Intraosseous mucoepidermoid carcinoma Mostly in posterior mandible
- Other odontogenic lesions Examples: calcifying epithelial odontogenic tumor, odontogenic myxoma, central odontogenic !broma
Unilocular Radiolucencies: Other Locations
ddx
- Developing tooth bud Within alveolar bone —
- Lateral radicular cyst Nonvital tooth; lateral canal
- Nasopalatine duct cyst Between and apical to maxillary central incisors; palatal swelling may occur
- Lateral periodontal cyst Especially in mandibular bicuspid-cuspid region
- Residual (periapical) cyst Edentulous area
- Odontogenic keratocyst —
- Central giant cell granuloma Especially in anterior mandible
- Stafne bone defect Angle of mandible below mandibular canal
- Cemento-osseous dysplasia Early stage; usually in young adult and middle-aged black women; usually in mandible
- Central ossifying !broma Early-stage lesion
- Ameloblastoma Especially unicystic type
- Buccal bifurcation cyst Buccal aspect of erupting mandibular !rst or second molar
- Other odontogenic cysts and tumors Examples: ameloblastic !broma, central odontogenic fibroma, calcifying odontogenic cyst Chapter
- Langerhans cell histiocytosis “Histiocytosis X”; usually in children or young adults
- Melanotic neuroectodermal tumor of infancy Anterior maxilla; may be pigmented
- Median palatal cyst Clinical midline swelling of hard palate
- Schwannoma/ neurofibroma Usually associated with mandibular nerve
Multilocular Radiolucencies
- Odontogenic keratocyst —
- Ameloblastoma Especially in posterior mandible; often associated with impacted tooth
- Central giant cell granuloma Especially in anterior mandible
- Ameloblastic fibroma Especially in young patients
- Odontogenic myxoma “Cobweb” trabeculation 679 * Central odontogenic !broma —
- Calcifying epithelial odontogenic tumor Often associated with impacted tooth
- Orthokeratinized odontogenic cyst Often associated with impacted tooth
- Lateral periodontal cyst (botryoid type) Especially in mandibular bicuspid-causpid region
- Calcifying odontogenic cyst Especially in cases with minimal or no calcifications; often associated with impacted tooth
- Central hemangioma/ arteriovenous malformation Especially in younger patients; may have honeycombed radiographic appearance; may pulsate
- Aneurysmal bone cyst Especially in younger patients
- Cherubism Hereditary; onset in childhood; multiple quadrants involved
- Hyperparathyroidism (brown tumor) Usually elevated serum calcium levels
- Intraosseous mucoepidermoid carcinoma Usually in posterior mandible
- Fibrous dysplasia Very rarely on panoramic !lms of mandibular lesions
Unilocular Radiolucencies:Periapical Location
DDX
- Periapical granuloma Nonvital tooth
- Periapical cyst Nonvital tooth
- Periapical cementoosseous dysplasia (early) Especially in black females; usually apical to mandibular anteriors; teeth are vital
- Periapical scar Usually endodontically treated tooth with destruction of cortical plate
- Dentin dysplasia type I Multiple periapical granulomas or cysts; shortened, malformed roots
Radiolucencies: Poorly Defined or Ragged Borders
DDx
Bold and underlines most likely
Bold second most likely
italic least likely
- Periapical granuloma or cyst Nonvital tooth
- Focal osteoporotic marrow defect Especially edentulous areas in posterior mandible; more common in females
- Osteomyelitis Usually painful or tender
- Medication-related osteonecrosis of the jaw Exposed necrotic bone; most often associated with bisphosphonate drugs
- Simple bone cyst Mandibular lesion that scallops up between roots of teeth; usually in younger patients
- Metastatic tumors Painful; paresthesia; usually in older adults
- Osteoradionecrosis History of radiation therapy; painful
- Multiple myeloma May be painful; in older adults
- Primary intraosseous carcinomas Odontogenic or salivary origin
- Osteosarcoma Often painful; usually in young adults
- Chondrosarcoma —
- Ewing sarcoma Usually in children
- Other primary bone malignancies Examples: !brosarcoma, lymphoma —
- Desmoplastic fibroma of bone Especially in younger patients
- Massive osteolysis Phantom (vanishing) bone disease
Radiopacities: Poorly Demarcated Borders
DDx
- Cemento-osseous dysplasia Late stage lesions; especially in middle-aged and older black women; usually in mandible
- Medication-related osteonecrosis of the jaw Sclerosis of alveolar crestal bone; exposed necrotic bone; most often associated with bisphosphonate drugs
- Condensing osteitis Usually at apex of nonvital tooth
- Sclerosing osteomyelitis May be painful
- Fibrous dysplasia “Ground glass” appearance; onset usually in younger patients
- Paget disease of bone “Cotton wool” appearance; late-stage lesions; in older patients
- Proliferative periostitis “Onion-skin” cortical change; in younger patients; often associated
- with nonvital tooth
- Osteosarcoma May have “sunburst” cortical change; frequently painful; usually in young adults
- Chondrosarcoma —
Radiopacities: Multifocal or Generalized
DDx
- Florid cemento-osseous dysplasia Late-stage lesions; especially in middle-aged and older black women; usually in mandible
- Medication-related osteonecrosis of the jaw Multifocal sites of involvement; sclerosis of alveolar crestal bone; exposed necrotic bone; most often associated with bisphosphonate drugs
- Idiopathic osteosclerosis Occasionally may be multifocal
- Paget disease of bone “Cotton wool” appearance; late-stage lesions; in older patients; more common in maxilla
- Gardner syndrome Multiple osteomas; epidermoid cysts; gastrointestinal polyps with high tendency toward malignant transformation; hereditary
- Polyostotic fibrous dysplasia “Ground glass” appearance; onset usually in younger patients; may be associated with café au lait skin pigmentation and endocrine abnormalities (McCune-Albright syndrome)
- Osteopetrosis Hereditary; recessive form may be associated with secondary osteomyelitis, visual and hearing impairment
Mixed Radiolucent/Radiopaque Lesions: Well-Demarcated Borders
- Developing tooth —
- Cemento-osseous dysplasia Intermediate-stage lesions; especially in middle-aged black women; usually in mandible
- Odontoma Compound or complex type; in younger patients; may prevent eruption of teeth
- Central ossifying fibroma —
- Ameloblastic fibroodontoma Usually in children
- Adenomatoid odontogenic tumor Usually in anterior region of jaws; most often with maxillary canine; usually in teenagers
- Calcifying epithelial odontogenic tumor Pindborg tumor; often associated with impacted tooth; may show “driven snow” opacities
- Calcifying odontogenic cyst Gorlin cyst; may be associated with odontoma
- Osteoblastoma/osteoid osteoma Intermediate-stage lesion; usually in younger patients; often painful
- Cementoblastoma Intermediate-stage lesion; attached to tooth root
Mixed Radiolucent/Radiopaque Lesions: Poorly Demarcated borders
- Medication-related osteonecrosis of the jaw Exposed necrotic bone; most often associated with bisphosphonate drugs
- Osteomyelitis With sequestrum formation or with sclerosing type; often painful
- Metastatic carcinoma Especially prostate and breast carcinomas; may be painful
- Osteosarcoma/ chondrosarcoma May be painful
Mixed Radiolucent/Radiopaque Lesions: Multifocal or Generalized
DDx
- Florid cemento-osseous dysplasia Intermediate-stage lesions; especially in middle-aged black women; usually in mandible
- Medication-related osteonecrosis of the jaw Exposed necrotic bone; most often associated with bisphosphonate drugs
- Paget disease of bone In older patients; more common in maxilla
Unique Radiographic Appearances: “Ground Glass” (Frosted Glass) Radiopacities
- Fibrous dysplasia Onset usually in younger patients
- Hyperparathyroidism May cause loss of lamina dura
Unique Radiographic Appearances: “Cotton Wool” Radiopacities
Ddx
- Cemento-osseous dysplasia Especially in middle-aged black women; usually in mandible
- Paget disease of bone In older patients; more common in maxilla
- Gardner syndrome Multiple osteomas; epidermoid cysts; gastrointestinal polyps with high tendency toward malignant transformation; hereditary
- Gigantiform cementoma Hereditary; facial enlargement may be present
Unique Radiographic Appearances: “Sunburst” Radiopacities
- Osteosarcoma Often painful; usually in young adults
- Intraosseous hemangioma Especially in younger patients
Unique Radiographic Appearances: “Onion-Skin” Radiopacities
DDx
- Proliferative periostitis In younger patients; often associated with nonvital tooth; best seen with occlusal radiograph
- Ewing sarcoma In young children
- Langerhans cell histiocytosis “Histiocytosis X”; usually in children or young adults
Soft Tissue Radiopacities
- Amalgam tattoo Markedly radiopaque; associated with surface discoloration
- Other foreign bodies Examples: bullet fragments, shotgun pellets —
- Sialolith Glandular pain may be present while patient is eating
- Tonsilloliths Superimposed on mandibular ramus
- Phlebolith May occur in varicosities or hemangiomas
- Calcified lymph nodes Example: tuberculosis
- Osseous and cartilaginous choristomas Most common on tongue
- Calcinosis cutis May be seen with systemic sclerosis (especially CREST syndrome)
- Myositis ossificans Reactive calcification in muscle
Hyperdontia (Extra Teeth)
DDx
- Idiopathic supernumerary teeth Mesiodens, paramolar, distomolar
- Cleft lip and palate Extra lateral incisor or canine 1
- Gardner syndrome Osteomas and gastrointestinal polyps
- Cleidocranial dysplasia Hypoplastic or missing clavicles; failure of tooth eruption
Macrodontia (Larger Than Normal Teeth)
- Fusion Joining of two tooth germs
- Gemination Incomplete splitting of a tooth germ
- Idiopathic macrodontia —
- Facial hemihyperplasia* Affected side only; nondental tissues also enlarged
- Gigantism Abnormally tall stature
Microdontia (Smaller Than Normal Teeth)
DDx
- Supernumerary teeth Mesiodens; fourth molars
- Peg-shaped lateral incisors Cone-shaped teeth
- Dens invaginatus Cone-shaped teeth; tendency for pulpal death and periapical pathosis
- Idiopathic microdontia Usually generalized
- Hereditary hypohidrotic ectodermal dysplasia
- Cone-shaped teeth; sparse, blond hair; diminished sweating
- Radiotherapy during childhood Stunted tooth development
- Congenital syphilis Hutchinson’s incisors
- Hypopituitarism Associated dwarfism
Malformed Crown
DDx
- Mesiodens and other supernumeraries Cone-shaped teeth or microdont
- Environmental enamel hypoplasia Example: high fever during tooth development
- Peg-shaped lateral incisors Cone-shaped teeth
- Dens invaginatus Cone-shaped teeth; tendency toward pulpal death and periapical pathosis
- Turner tooth Infection or trauma to associated primary tooth
- Fusion or gemination “Double” tooth
- Talon cusp Extra cusp on lingual of anterior tooth
- Dens evaginatus Extra cusp on occlusal of premolar tooth
- Amelogenesis imperfecta Hereditary defect in enamel formation
- Dentinogenesis imperfecta Fracturing away of enamel due to hereditary defect in dentin formation; gray-yellow opalescent teeth; calcified pulp chambers
- Regional odontodysplasia Poor tooth formation in a focal area; “ghost teeth”
- Congenital syphilis Hutchinson’s incisors; mulberry molars
- Vitamin D–resistant rickets Hereditary condition; high pulp horns
- Renal osteodystrophy Abnormal calcium and phosphate metabolism
- Hypoparathyroidism Possible associated endocrine-candidiasis syndrome
- Pseudohypoparathyroidism —
- Epidermolysis bullosa Hereditary blistering skin disease
- Radiotherapy during childhood Stunted tooth development
- Globodontia Associated with otodental syndrome
- Lobodontia Cusp anatomy resembles teeth of carnivores
Enamel Loss After Tooth Formation
F. Enamel Loss After Tooth Formation
*** Caries — —
*** Trauma Fractured tooth —
*** Attrition Physiologic loss of tooth structure 55
*** Abrasion Pathologic loss of tooth structure 56
** Erosion Chemical loss of tooth structure 56
* Dentinogenesis imperfecta Hereditary defect in dentin formation; poor junction between
enamel and dentin
98
* Amelogenesis imperfecta Hereditary defect in enamel formation; especially hypocalcified
types
92
Extrinsic Staining of Teeth
DDx
- Tobacco Black or brown
- Coffee, tea, and cola drinks Brown or black
- Chromogenic bacteria Brown, black, green, or orange 63
- Chlorhexidine Yellow-brown 63
H. Intrinsic Discoloration (“Staining”) of Teeth
- Aging Yellow-brown; less translucency —
- Death of pulp Gray-black; less translucency
- Fluorosis White; yellow-brown; brown; mottled
- Tetracycline Yellow-brown; yellow fluorescence
- Internal resorption “Pink tooth of Mummery”