dietry aspects of anemia Flashcards

1
Q

what type of anaemia results from iron deficiency

A

hypochromic microcytic anameia

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2
Q

what type of anaemia results from folate/B12 deficiency

A

megaloblastic anaemia

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3
Q

what is the most widespread nutritional problem in the world

A

iron deficiency

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4
Q

what demographic groups have the highest percentage of Hb below threshold

A

girls 11-18; adult women; men >65 (generally secondary cause e.g. colon cancer)

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5
Q

how much iron is recycled in the body daily and from where

A

20-25mg recycled from red cell destruction

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6
Q

4 risk factors for iron deficiency anaemia

A

H.pylori (use iron for own growth); long-term use of PPIs; blood loss (menstrual, frequent donation); pregnancy

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7
Q

what vitamin increase iron absorption

A

vitamin C

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8
Q

what are 2 dietary factors that decrease iron absorption and where r they found

A

phytate (in whole grain cereals); tannins (in fruit, veg, tea)

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9
Q

how much meat is recommended per day

A

no more than 70g of red/processed meat

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10
Q

4 fucntions of vit B12 (cobalamin)

A
  1. development/myelination/function of CNS;
  2. DNA synthesis (and thus RBC formation);
  3. co-factor methionine synthase
  4. L-methylmalonyl-CoA-mutase
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11
Q

why might serum ferratin levels be artificially high

A

it is an acute phase protein and so does not reflect iron stores when there is infection/inflammation present

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12
Q

how much iron needs to be absorbed per day

A

1-2mg

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13
Q

what are the 3 main reasons for iron deficency in industrialised countries

A
  1. low bioavailability;
  2. sedentary lifestyle;
  3. lower micronutrient density
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14
Q

what is the majority of B12 deficiency caused by

A

impaired absoprtion (pernicious anaemia) due to lack of intrinsic factor

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15
Q

long term use of what kind of drugs can result in B12 deficiency and why

A

PPIs (and other drugs that affect gastric acid production) -> gastric acid needed to release B12 bound to proteins in food

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16
Q

what can inadequate B12 in children result in

A

stunted brain growth and intellectual development

17
Q

where is Vit B12 found in the diet

A

products of animal origin - meat (esp liver), poultry, fish, dairy, eggs;
fermented foods e.g. sauerkraut (due to bacteria);
fortified cereals

18
Q

folate vs folic acid

A

Folate - natural form of vitamin B9 in food
folic acid -synthetic form

19
Q

what enzyme deconjugates folic acid in the small intestine

A

glutamate carboxypeptidase II

20
Q

what increases folate/folic acid requirements

A

alcohol consumption

21
Q

what demographics are vulnerable to nutritional anaemias

A

infants/chidlren (high requirements); vegans; pregnant women; elderly (malabsorption and poor diet); low income; ethnic minorities

22
Q

4 symptoms of iron deficiency in infants

A

poor weight gain; frequent infections; developemental delay; behavioural disorders

23
Q

why might an infant develop iron deficiency at 6 months old

A

inappropriate weaning

24
Q

how much does iron absorption increase by in pregnancy

A

x1.5 in second trimester and x4 in third

25
Q

what 2 mutations cause increased risk of
neural tube defect in the foetus

A

Methyl tetrahydrofolate reductase (MTHFR) and methionine synthetase reductase (MTRR) mutations

26
Q

why is anaemia common in the elderly (8)

A
  1. Higher risk of nutritional deficiencies
  2. Impaired absorption (particularly vitamin B12)
  3. Dental problems – restricted food choice
  4. Poor quality meals in institutions
  5. Lower socio-economic status
  6. Less mobile – restricted shopping
  7. Mental problems – dementia, depression
  8. Lower physical activity requires lower energy intake
27
Q

management for folate deficiency

A

5mg folic acid supplement OD; eat folate rich foods e.g broccoli, Brussels sprouts, asparagus, peas, chickpeas, and brown rice

28
Q

elevate what can be a sign of folate deficicency

A

homocystein levels (with normal methylmalonyl-coenzyme A)

29
Q

6 causes of splenomegaly

A
  1. haematological malignancy (lymphoma, leukemia, mylofibrosis);
  2. haematological conditions (chronic haemolytic anaemia);
  3. infection (EBV, maralia, leishmaniasis);
  4. liver disease (cirrhosis results in increased portal hypertension);
  5. sarcoidosis, SLE etc.
  6. glycogen storage disorders (gaucher’s etc.)