DIC

Question 1

What is the pathophysiology f DIC?

Answer 1

Release of procoagulants into system caused widespread activation of clotting, leading to consumption of clotting factors and therefore increased risk of bleeding

Question 2

What can cause DIC?

Answer 2

Sepsis
Trauma
MAlignancy
Major haemorrhage

Question 3

What is the presentation of DIC?

Answer 3

Microvascular clots- chest pain, SOB, leg pain
Extensive bleeding from anywhere- haematuria, from puncture sites
Bruising
Multiorgan failure

Question 4

What investigations are done for DIC?

Answer 4

FBC- low platelets
D dimer elevated
Coagulation- prolonged PT, APTT and bleeding time

Question 5

What is the management of DIC?

Answer 5

Treat cause
Replacements- FFP, cryoprecipitate
Platelets <50= give platelets

Question 6

What are some complications of DIC?

Answer 6

AKI
Life threatening thrombosis of haemorrhage
Hypovolaemic shock
Haemothorax
Gangrene

Question 7

What is the prognosis of DIC?

Answer 7

Poor- 20-50% mortality

Sepsis associated with poor outcomes