Diarrhoea Drugs

Question 1

Name all them classes [6]

Answer 1

Opioid Agonists
Colloidal Bismuth Compounds
Lyophilizate - think Bacteria!
Somatostain-like Peptide [somatostatin impt hormone!]
Bile Salt binding resin - think Bile!
Mass - Hard mass of kaolin, pectin

Question 2

Opioid Agonists

2 Names
MOA
AE

Answer 2

Loperamide
Diphenoxylate

• ENS, increase colonic transit time, slow down

Loperamide dont cross BBB
Diphenoxylate can have dependence hence given w atropine, muscarinic antagonist - dry mouth

Question 3

Bismuth

Answer 3

Bismuth Subsalicylate - salicylate block PG production, closing Cl channels

MOA: mucosal protection, binds enterotoxin to treat TD
AE: black tongue, black stools, Bismuth toxicity encephalopathy

Question 4

Lyophilizate

AE

Answer 4

Lacteol Forte

• adheres to intestinal cells, normalize foreign bacteria, block colonization of invasive bacteria;

AE: lactose intolerance

Question 5

Kaolin and Pectin

MOA
AE

Answer 5

Absorbent of bacterial toxins and fluid; indigestive

AE: bind to and block absorption of other drugs

Question 6

Bile Salt-binding resins

MOA
AE

Given a disease that require this

Answer 6

Cholestyramine

Malabsorption of bile salts (like in Crohn’s) leads to secretory diarrhea by excess bile salts;

these resins bind bile salts

AE: malabsorption of fats
Bind other drugs

Question 7

Somatostatin-like Peptides

how many syllabi

Answer 7

Octreotide

• Inhibitor of transmitters, hormones like Gastrin, VIP, decrease intestinal, pancreatic secretions, GI motility, GB contraction

Used in Carcinoids, VIPoma, Vagotomy leading to dumping of food;

AE: steatorrhea, Fat vitamins; Gall stones from less GB contraction

Question 8

What needs to be given for all

Answer 8

Water

Question 9

Whats Diphenoxylate

Answer 9

Opioid Agonist given w Atropine

Question 10

Whats Loperamide

Answer 10

Opioid Agnoist

Question 11

Whats Octreotide

Answer 11

Somatostatin-like peptide