Diarrhea treatment (antimicrobials)- #3 Flashcards
Treatment: Entamoeba histolytica
metronidazole for activate state
iodoquinol for carrier state
MOA metronidazole
entry into organism, reductive activation by intracellular transport proteins, reduced metronidazole disrupts nucleic acid synthesis
Forms free radical toxic metabolites in the bacterial cell that damage DNA
Treatment: Rotavirus
rehydration
Treatment: Norovirus
self limited, usually no treatment
rehydration if severe fluid loss
Treatment: Giardia
metronidazole or tinidazole
Treatment: cryptosporidium parvum
supportive care
Treatment: shigella
ciprofloxacin (fluoroquinolones)
MOA: ciprofloxacin - fluoroquinolones
DNA Gyrase inhibitor (aka topoisomerase)
Treatment: Staph aureus
supportive - self-limited
Treatment: B. cereus
rehydration
Treatment: c. diff
metronidazole or ORAL vancomycin (not absorbed, acts on intestinal bacteria)
MOA vancomycin:
inhibits cell wall synthesis (inhibits peptidogylcan synthesis)
Treatment: yersinia
self-limited
Treatment: vibrio cholera
ciprofloxacin or docycline
MOA doxycycline
inhibits protein synthesis (binds 30s subunit)
