Diabetic retinopathy Flashcards
1
Q
Pathophysiology of DR
A
- Hypergycaemia
- chronic inflammation
- retinal neurodegeneration
2
Q
Consequences of hyperglycaemia
A
Vessel dilation
Pericytes loss
BRB loss
3
Q
How does BRB loss cause haems
A
BM thickening Capillary occlusion Ischaemia VEGF Neovas Leaky vessels Haems
4
Q
Consequences of chronic inflammation
A
- leukostasis
- endothelial cell adhesion molecules
- chemokines
- inflammatory cytokines
- glial cells
5
Q
DR risk factors
A
- age
- disease duration
- blood glucose control
- lifestyle
- poor micro-circulation
6
Q
AC Complications
A
- diabetic keratopathy
- dry eye
- diabetic rubeosis
7
Q
Loss of corneal nerves can lead to:
A
Corneal neuropathy Loss of corneal sensation Poor wound healing Neutrophic ulcers Susceptibility to corneal erosions/infections Post-surgical complications
