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Ocular Conditions > AMD > Flashcards

AMD Flashcards

1
Q

4 key processes driving disease progression

A

Lipofuscin formation
Drusen formation
Inflammation
Neovas

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2
Q

Formation of lipofuscin

A

Photoreceptors shed used discs

  • fuse with RPE lysosomes -> phagolysosomes
  • incomplete degradation -> residual bodies -> substrate for lipofuscin
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3
Q

Aetiology

A

Changes in BM
Vascular insufficiency
Genetics
Oxidative stress

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4
Q

BM changes with age

A

Membrane conductivity decreases

Lipid content increases

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5
Q

Vascular insufficiency affects

A

Changes to choroidal circulation

  • affect diffusion of substances/gases across RPE-BM
  • removal of waste products slows down
  • waste accumulation
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Ocular Conditions (4 decks)

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