Diabetes pharm Flashcards
oral incretin mimetic
semaglutide
twice daily mimetics
exenatide
one daily mimetics
liraglutide, lixizenatide
once weekly mimetic
exenatide ER, Trulicity, ozempic
GLP-1 agonist MOA
enhances glucose dependent insulin secretion by the beta cells, suppresses glucagon secretion, slows gastric emptying, increases satiety
indication for incretin mimetics
monotherapy or adjunct therapy in patients taking metformin, SU, or TZD
3 day window for missed dose – glp agonist
exenatide ER, albigulutide, dulaglutide
5 day window for missed dose – glp agonist
5 day window for missed dose
rapid acting insulin types
insulin lispro, insulin aspart, insulin gluisine, inhaled human insulin
insulin lispro brand name
humalog
insulin lispro onset
15-30 minutes
insulin aspart brand name
novolog and fiasp
novolog onset
15-30 minutes
fiasp onset
5-20 minutes
insulin glulisine brand name
apidra
apidra onset
15-30 minutes
inhaled human insulin brand name
afrezza
afrezza onset
12-15 minutes
peak time for rapid-acting insulin
1-2 hours
duration for rapid acting insulin
3-5 hours
2.5-3 for afrezza
short acting insulin
regular insulin (U-100)
regular insulin brand name
Humulin R, Novolin R
onset for short acting
30-60 minutes
peak for short acting
2-3 hours
duration for regular insulin
6-8 hours
intermediate-acting insulin
NPH insulin, regular insulin (U-500)
NPH insulin brand name
Humulin N, Novolin N
NPH onset
2-4 hours
NPH peak
4-6 hours
NPH duration
8-12 hours
regular insulin U-500 brand
Humulin R
Humulin R onset
30-60 minutes
Humulin R peak
2-3 hours
Humulin R duration
15-24 hours
long-acting insulin
insulin detemir, insulin glargine 100 and 300, insulin degludec
long acting insulin peaks
relative flat peak
insulin detemir brand
Levemir
insulin detemir onset
2-4 hours
insulin detemir duration
14-24 hours
insulin glargine 100 brand
lantus
lantus onset
2-4 hours
lantus duration
22-24 hours
insulin glargine 300 brand name
toujeo
toujeo onset
6 hours
toujeo duration
24-30
insulin degludec brand
tresiba
Tresiba onset
30-90 minutes
Tresiba duration
42 hours
Humulin 70/30
70% NPH and 30% regular insulin
Novolin 70/30
70% NPH and 30% regular insulin
Humalog 75/25
75% insulin lispro protamine suspension with 25% insulin lispro
Humalog 50/50
50% insulin lispro protamine suspension with 50% insulin lispro
NovoLog 70/30
70% insulin aspart protamine suspension with 30% insulin aspart
lispro timing before food
0-15 minutes
aspart timing before food
0-15 minutes
5 ac; 20 pc
glulisine timing before food
0-15 min
afrezza timing before food
0 min
regular insulin 100 timing before food
30 min
NPH mix
lispro, aspart, regular
