Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

pharm > diabetes meds > Flashcards

diabetes meds Flashcards

1
Q

give type/mechanism: lispro

A

insulin, rapid acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

give type/mechanism: aspart

A

insulin, rapid acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

give type/mechanism: glulisine

A

insulin, rapid acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

give type/mechanism: “regular” insulin

A

insulin, short acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

give type/mechanism: NPH

A

insulin, intermediate acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

give type/mechanism: glargine

A

insulin, long acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

give type/mechanism: detemir

A

insulin, long acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

give type/mechanism: metformin

A

biguanide, reduces hepatic glucose output

decreases gluconeogenesis
increases glycolysis
increases peripheral glucose uptake (insulin sensitivity)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

give type/mechanism: tolbutamide

A

1st gen sulfonylurea

close K+ channel in beta cell so cell depolarizes triggering insulin release via Ca2+ influx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

give type/mechanism: chlorpropamide

A

1st gen sulfonylurea

close K+ channel in beta cell so cell depolarizes triggering insulin release via Ca2+ influx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

give type/mechanism: glyburide

A

2nd gen sulfonylurea

close K+ channel in beta cell so cell depolarizes triggering insulin release via Ca2+ influx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

give type/mechanism: glimepiride

A

2nd gen sulfonylurea

close K+ channel in beta cell so cell depolarizes triggering insulin release via Ca2+ influx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

give type/mechanism: glipizide

A

2nd gen sulfonylurea

close K+ channel in beta cell so cell depolarizes triggering insulin release via Ca2+ influx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

give type/mechanism: pioglitazone

A

glitazone/thiazolidinediones

binds to PPAR-gamma nuclear transcription regulator –> increases insulin sensitivity in peripheral tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

give type/mechanism: rosiglitazone

A

glitazone/thiazolidinediones

binds to PPAR-gamma nuclear transcription regulator –> increases insulin sensitivity in peripheral tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

give type/mechanism: acarbose

A

alpha-glucosidase inhibitor

inhibits intestinal brush border alpha glucosidases. delayed sugar hydrolysis and glucose absorption –> decreased postprandial hyperglycemia

17
Q

give type/mechanism: miglitol

A

alpha-glucosidase inhibitor

inhibits intestinal brush border alpha glucosidases. delayed sugar hydrolysis and glucose absorption –> decreased postprandial hyperglycemia

18
Q

give type/mechanism: pramlintide

A

amylin analog

decreases gastic emptying
decreases glucagon

(amylin is cosecreted with insulin from the pancreatic β-cells and acts centrally to slow gastric emptying, suppress postprandial glucagon secretion, and decrease food intake)

19
Q

give type/mechanism: exenatide

A

GLP-1 analog

increase insulin
decrease glucagon release

(GLP-1 is secreted by intestinal L cells in response to food intake and stimulates proinsulin gene transcription and glucose dependent insulin secretion, slows gastric emptying, promotes satiety, reduces food intake, inhibits glucagon secretion)

20
Q

give type/mechanism: liraglutide

A

GLP-1 analog

increase insulin
decrease glucagon release

(GLP-1 is secreted by intestinal L cells in response to food intake and stimulates proinsulin gene transcription and glucose dependent insulin secretion, slows gastric emptying, promotes satiety, reduces food intake, inhibits glucagon secretion)

21
Q

give type/mechanism: linagliptin

A

DPP-4 inhibitor

increase insulin
decrease glucagon release

DPP-4 enzyme inactives GLP-1

22
Q

give type/mechanism: saxagliptin

A

DPP-4 inhibitor

increase insulin
decrease glucagon release

DPP-4 enzyme inactives GLP-1

23
Q

give type/mechanism: sitagliptin

A

DPP-4 inhibitor

increase insulin
decrease glucagon release

DPP-4 enzyme inactives GLP-1

24
Q

contraindication of Metformin

A

can cause lactic acidosis, so contraindicated for anyone predisposed to that: heart failure, liver disease, severe hypoxia, renal insufficiency

25
Q

contraindication of sulfonylureas

A

hepatic dysfunction

26
Q

what diabetes medication is best for people with renal dysfunction?

A

Glipizide (undergoes hepatic clearance)

27
Q

side effect of Thiazolidinediones

A

fluid retention, peripheral edema (contraindication: heart failure)

pharm (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions