anti-arrhythmics

Question 1

quinidine - class

Answer 1

class IA anti-arrythmic

Question 2

procainamide - class

Answer 2

class IA anti-arrythmic

Question 3

disopyramide - class

Answer 3

class IA anti-arrythmic

Question 4

Which class of drugs treats Wolf-Parkinson-White?

Answer 4

class IA anti-arrythmic

Question 5

side effect of all class IA anti-arrythmics?

Answer 5

arrhythmias (include torsades de pointes)

Question 6

which anti-arrhythmic is associated with vertigo, headache, tinnitus and psychosis (and what is that called?)?

Answer 6

quinidine (cinchonism)

Question 7

which anti-arrhythmic can cause drug induced lupus (as well as psychosis)?

Answer 7

procainamide

Question 8

which anti-arrhythmic can cause urinary retention, double vision, and constipation?

Answer 8

disopyramide

Question 9

how do class IA anti-arrythmics act?

Answer 9

bind to activated sodium channels –> prolonged phase 0 depolarization (phase 3 repolarization is also delayed)

Question 10

how do class IB anti-arrythmics act?

Answer 10

bind to both activated and inactivated sodium channels

Question 11

lidocaine - class

Answer 11

class IB anti-arrythmic

Question 12

tocainide - class

Answer 12

class IB anti-arrythmic

Question 13

mexiletine - class

Answer 13

class IB anti-arrythmic

Question 14

side effect of all class IB anti-arrythmics?

Answer 14

arrythmias

Question 15

flecainide - class

Answer 15

class IC anti-arrythmic

Question 16

encainide - class

Answer 16

class IC anti-arrythmic

Question 17

propafenone - class

Answer 17

class IC anti-arrythmic

Question 18

patients with ______ should not be treated with class IC anti-arrythmics?

Answer 18

structurally abnormal heart (ex: post MI)

Question 19

sotalol - class

Answer 19

class III anti-arrhythmic (with potent beta blocking activity)

Question 20

ibutilide - class

Answer 20

class III anti-arrhythmic

Question 21

dofetilide - class

Answer 21

class III anti-arrhythmic

Question 22

amiodarone - class

Answer 22

class III anti-arrhythmic

Question 23

bretylium - class

Answer 23

class III anti-arrhythmic

Question 24

how do class III anti-arrhythmics work?

Answer 24

bind potassium channels –> prolonged phase 3 repolarization

Question 25

side effects for amiodarone

Answer 25

pulmonary fibrosis, hepatotoxicity, thyroid dysfunction, cardiac arrhythmias, ataxia, photosensitivity

Question 26

mechanism of amiodarone

Answer 26

classified as class III but has class I-IV activity

Question 27

verapamil - class

Answer 27

class IV anti-arrhythmic

Question 28

diltiazem - class

Answer 28

class IV anti-arrhythmic

Question 29

class IV anti-arrhythmic mechanism

Answer 29

block calcium channels. blocking of calcium in SA and AV nodes –> slows phase 4 spontaneous depolarization (prolonged PR interval). also delays repolarization of myocytes

Question 30

what can be used to suppress ectopic pacemakers especially when associated with digoxin toxicity?

Answer 30

potassium

Question 31

what can be used to treat torsades de points as well as digoxin toxicity?

Answer 31

magnesium

Question 32

moricizine - class

Answer 32

class IC anti-arrhythmic

Question 33

drugs that can’t be used in people with long QT syndrome (8)

Answer 33

quinidine, procainamide, sotalol, amiodarone, disopyramide, dofetilide, phenothizines and tricyclic antidepressants