Diabetes Insipidus Flashcards
1
Q
Diabetes insipidus- 2 types
A
Cranial diabetes insipidus- Decreased ADH secretion from pituitary
Nephrogenic diabetes insipidus- renal insensitivity to ADH
2
Q
Cranial causes of diabetes insipidus
A
Post head injury
Idiopathic
Craniopharyngiomas
Wolfram’s syndrome
3
Q
Nephrogenic causes of diabetes insipidus
A
Genetic
Hypercalcaemia, hypokalaemia
Lithium
Tubulo-interstitial disease
4
Q
Symptoms
A
Polyuria and polydipsia
High plasma osmolality, low urine osmolality.
Do a water deprivation test.
5
Q
Treatment
A
Nephrogenic- thiazides, low salt and protein diet
Cranial- desmopressin
6
Q
Syndrome of inappropriate ADH secretion -SIADH.
What is it?
What causes it?
A
Hyponatraemia 2nd to dilutional effects of excessive water retention.
Seen in SCLC, neurological events e.g. stroke, haemorrhage.
