Diabetes insipidus

Question 1

diabetes insipidus

Answer 1

= large amounts of dilute urine produced = extreme thirst

Question 2

types of diabetes insipidus

Answer 2

1. Cranial = HYPOTHALAMUS NOT MAKE ENOUGH ADH
   tx = vasopressin/desmopressin
2. Nephrogenic = tx thiazides diuretics;
   KIDNEY NOT RESPOND TO ADH

Question 3

Desmopressin

Answer 3

more potent analogue of vasopressin with longer duration of action + no vasoconstrictor effects

Question 4

Desmopressin use

Answer 4

~ diabetes insipidus
~ Nocturnal enuresis

Question 5

Desmopressin SE

Answer 5

Hyponatraemic convulsions

Question 6

SIADH (syndrome of inappropriate anti-diuretic hormone) secretion

Answer 6

~ hypONatraemia caused by inappropriate secretion of ADH

tx = fluid restrict !!!
if not enough
~ demeclocycline = blocks renal tubular effects ADH
~ Tolvaptan = vasopressin antagonist

AVOID rapid correction as osmotic demyelination of neuron risk = serious CNS effects