Cushings

Question 1

Cushings syndrome

Answer 1

characterised by hypercortisolism (high cortisol)

Question 2

Cushings symptoms

Answer 2

~ skin thinning
~ bruising
~ stretch marks red/purple
~ striae
~ fat deposits on face
~ MOON FACE
~ ACNE
~ HIRSUTISM
~ Amenorrhoea

Question 3

Cushings caused by

Answer 3

~ steroid withdrawal / reduced dose
~ tumour

Question 4

Cushings tx

Answer 4

~ ketoconazole
~ cortisol-inhibiting drugs

Question 5

cortisol-inhibiting drugs

Answer 5

1. Metyrapone
2. Ketoconazole (potent)

Question 6

counselling on cortisol-inhibiting drugs

Answer 6

Adrenal insufficiency
- look out for fatigue, anorexia, N,V, hypotension
- insufficiency causes = hyPO-Na, hyPER-K, hyPO-glycaemia