diabetes drugs Flashcards
example of sulfonylurea
glipizide
example of SGLT2 inhibitor
dapagliflozin
glow glitter so girly
example of GLP1 mimetic
exenatide
tide, skinny for the beach, ozempic
number 1 water, beach
example of DPP4 inhi
sitagliptin
dip, glip
side effects of sulfonylureas
Hypoglycaemic episodes
Increased appetite and weight gain
Syndrome of inappropriate ADH secretion
Liver dysfunction (cholestatic)
side effect of DPP4 i
Pancreatitis
contraindications to DPP4 i
pancreatitis, heart failure, angiodema, DKA
contraindications to GLP1
pancreatitis, CKD, thyroid cancer
contraindications to sulfonylureas
CKD, liver failure
contraindications to pioglitazone
osteoporosis, heart failure, bladder cancer
contraindications to metformin
CKD`, heart disease, liver failure, metabloic acidosis
contraindications to SGLT2 i
renal impairment
side effects pioglitazones
Weight gain
Fluid retention- contraindi ated in HF
Liver dysfunction
Fractures
side effects of metformin
Gastrointestinal side-effects
Lactic acidosis
management of t2dm target hba21c
you can titrate up metformin and encourage lifestyle changes to aim for a HbA1c of 48 mmol/mol (6.5%), but should only add a second drug if the HbA1c rises to 58 mmol/mol (7.5%)
what should you add to metformin if CVD risk, Q risk of >=10% or chronic heart failure
SGLT2 i
metformin should be established and titrated up before introducing the SGLT-2 inhibitor
If metformin is contraindicated but patient doesnt have CVD risk, Q risk of >=10% or chronic heart failure what give
DPP-4 inhibitor or pioglitazone or a sulfonylurea
dka insulin management rate of inf
IV insulin infusion should be started at 0.1 unit/kg/hour
