Diabetes Flashcards
What is type 1 diabetes?
An absolute deficiency of insulin
What is type 2 diabetes?
Resistance to insulin action &an inadequate compensatory insulin secretory response
Where is glucose absorbed from?
small intestine into the blood
Where is an increase in concentration of blood glucose sensed by?
Beta-cells of the pancreas
Where do glucose transporters facilitate uptake of glucose for storage as glycogen?
The liver
what fasted plasma glucose level is diabetic?
> 7.0mmol/L
What random plasma glucose level is diabetic?
> 11.1mmol/L
What are symptoms of diabetes?
Increases thirst, increased nee to urinate, fatigue, tiredness, weight loss and blurred vision
Are symptoms more severe and set on faster in type 1 or 2 diabetes?
Type 1
What is the current prevalence of diabetes in the uk?
3.4 million
What is the aetiology of type 1 diabetes?
Autoimmune destruction on beta-cells, can occur at any age, famalilia trend, viruses, drugs or cehmical
What disorders is type 1 diabetes secondary to?
Pancreatitis
What % of type 2 diabetics are obese?
80%
How can type 2 diabetes be treated?
Lifestyle modification, oral hypoglycaemic agents or exogenous insulin therapy
How many years before diagnosis is type 2 diabetes detectable by?
10 Years
Name three identifications of metabolic syndrome?
blood pressure>130/>85 mm HG, Fasting glucose >6.1mmol/l and serum triglycerides >1.7mmol/l
What health outcomes can diabetes cause?
Neuropathy, Nepthropathy, retinopathy and microvascular complications
What is associated with diabetic complications?
Length of diabetes duration
What for of diabetes is more relevant to macrovascular complications?
Type 2
What macrovascualr complications can type2 diabetes cause?
Coronary heart disease, stroke, peripheral vascular disease and increased morality
What should type 2 diabetes aim to control?
Lipid factors and blood pressure
What blood glucose level is hypoglycemic (glucose deficient) when self monitoring?
< 4.0 mmol/l
What blood glucose level is hyperglycaemic (excessive glucose) when self monitoring?
persistently >12.0 mmol?l
Normal blood glucose level before meals?
4-7 mmol/l